킨세노사이드

킨세노사이드
킨세노사이드 구조식 이미지
카스 번호:
151870-74-5
한글명:
킨세노사이드
동의어(한글):
킨세노사이드
상품명:
Kinsenoside
동의어(영문):
Kinsenoside;(+)-Kinsenoside;(4R)-4-(beta-D-Glucopyranosyloxy)dihydro-2(3H)-furanone;2(3H)-Furanone, 4-(β-D-glucopyranosyloxy)dihydro-, (4R)-;(4R)-4-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxolan-2-one;(R)-4-(((2R,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)dihydrofuran-2(3H)-one;Keap1-Nrf2,Inhibitor,pulposus,disc,degeneration,Kinsenoside,inhibit,cells,nucleus,Nrf2,Apoptosis,intervertebral
CBNumber:
CB22645474
분자식:
C10H16O8
포뮬러 무게:
264.23
MOL 파일:
151870-74-5.mol

킨세노사이드 속성

끓는 점
570.2±50.0 °C(Predicted)
밀도
1.59±0.1 g/cm3(Predicted)
저장 조건
4°C, protect from light
용해도
DMF:14.0(Max Conc. mg/mL);52.98(Max Conc. mM)
DMSO:33.0(Max Conc. mg/mL);124.89(Max Conc. mM)
PBS (pH 7.2):10.0(Max Conc. mg/mL);37.85(Max Conc. mM)
물리적 상태
결정성 고체
산도 계수 (pKa)
12.81±0.70(Predicted)
색상
White to light yellow

안전

킨세노사이드 C화학적 특성, 용도, 생산

개요

Kinsenoside is a glycoside originally isolated from A. formosanus that has diverse biological activities, including antihyperlipidemic, immunosuppressive, and anti-inflammatory properties. It increases lipolysis mediated by adipose triglyceride lipase and increases hydrolysis of triglycerides in C3H10T1/2 adipocytes. It also increases phosphorylation of peroxisome proliferator-activated receptor α (PPARα) and CREB as well as protein levels of SIRT1, PGC-1α, and carnitine palmitoyltransferase I. Kinsenoside downregulates the expression and phosphorylation of VEGF receptor 2 (VEGFR2) and inhibits crosstalk between the JAK2/STAT3 and PI3K/AKT signaling pathways in dendritic cells in vitro. It decreases the production of IFN-γ, IL-17, and TNF-α and increases the production of IL-10 in splenocytes isolated from mice with collagen-induced arthritis (CIA). Kinsenoside (300 mg/kg per day) decreases the expression of IL-1β, TNF-α, and matrix metalloproteinase-9 (MMP-9) and increases the expression of IL-10 in inflamed joints in a mouse model of collagen-induced arthritis and prevents paw edema and reduces the severity of arthritis.

용도

Kinsenoside is an anti-hyperlipidemic agent isolated from the plant Anoect chilus.

킨세노사이드 준비 용품 및 원자재

원자재

준비 용품


킨세노사이드 공급 업체

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