블레스티시딘-에스
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블레스티시딘-에스 속성
- 녹는점
- 235°C
- 끓는 점
- 539.06°C (rough estimate)
- 알파
- D11 +108.4° (water)
- 밀도
- 1.1690 (rough estimate)
- 증기압
- Low
- 굴절률
- 1.6910 (estimate)
- 용해도
- DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble; Water: soluble
- 물리적 상태
- 고체
- 산도 계수 (pKa)
- 2.4 (carboxyl), 4.6,8.0 and>12.5 (three bases)
- 수용성
- >30g l-1(20°C)
- 안정성
- 강한 산화제와 호환되지 않습니다.
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | T+ | ||
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위험 카페고리 넘버 | 28 | ||
안전지침서 | 24/25-36/37-45 | ||
유엔번호(UN No.) | 3172 | ||
위험 등급 | 6.1(a) | ||
포장분류 | II | ||
HS 번호 | 29349990 | ||
유해 물질 데이터 | 2079-00-7(Hazardous Substances Data) | ||
독성 | LD50 i.v. in mice: 2.82 mg/kg (Takeuchi) | ||
기존화학 물질 | KE-01170 | ||
유해화학물질 필터링 | 97-1-117 | ||
함량 및 규제정보 | 물질구분: 유독물질; 혼합물(제품)함량정보: 블라스티시딘-에스과 그 염류 및 그 중 하나를 1% 이상 함유한 혼합물 |
블레스티시딘-에스 C화학적 특성, 용도, 생산
개요
Nucleoside antibiotic produced by Streptomyces griseochromogenes (1). Biosynthesized from cytosine, glucose, arginine, and methionine (2).용도
Blasticidin S is a nucleoside produced by several species of Streptomyces, first reported in the late 1950s. Blasticidin S is an antifungal agent with particularly potent activity against the rice pathogen, Piricularia oryzae, for which it was used commercially for some time in Japan. Blasticidin S inhibits protein synthesis and is active against bacteria, tumour cell lines and nematodes. More recently, blasticidin S has been used as a marker for strain manipulations. Blasticidin S provided by BioAustralis is presented as the free base to avoid problems associated with the use of the hydrochloride.정의
ChEBI: A blasticidin that is an antibiotic obtained from Streptomyces griseochromogene.생산 방법
Blasticidin S is produced by Streptomyces griseochromogenes, and has a wide range of antimicrobial activity (4). This antibiotic was utilized in the Far East beginning in 1961 against the rice blast pathogen Pyricularia oryzae, with effective control achieved at rates of 10–40 ppm (4).일반 설명
Blasticidin S was found in the culture broth of Streptomyces griseochromogenes by Yonehara et al. of the University of Tokyo in 1958. It has a nucleoside-analogue structure and shows strong activity against phytopathogenic fungi, especially Pericularia oryzae, the pathogen causing rice blast. Blasticidin S has been used to protect rice plants.Pharmacology
Inhibits protein synthesis both in eukaryotes and in prokaryotes (5,6). Interacts with ribosomal RNA in large subunit, interfering with the transpeptidation step. Inhibits cell-free protein synthesis in P. oryzae and Escherichia coli.신진 대사 경로
Several blasticidin S-resistant microorganisms are found to produce blasticidin S deaminase which catalyzes the hydrolytic deamination of the cytosine moiety in blasticidin S to give a non-toxic deaminohydroxy derivative.신진 대사
3H-blasticidin S administered to mice was excreted in the urine and feces within 24 h. Cytomycin and cytosin were identified as the main metabolites in and on rice plants, respectively (7). In soil, DT50 < 5 d. Metabolized to nontoxic deaminohydroxy blasticidin S by Aspergillus sp. and resistant Bacillus cereus. Novel deaminase and coding genes, BSD and bsr, were isolated as selectable marker genes for genetic engineering (8).블레스티시딘-에스 준비 용품 및 원자재
원자재
준비 용품
블레스티시딘-에스 공급 업체
글로벌( 50)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 |
linda@hubeijusheng.com | CHINA | 22968 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
factory@coreychem.com | China | 29823 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 |
1026@dideu.com | China | 8232 | 58 |
SUZHOU SENFEIDA CHEMICAL CO.,LTD | +86-0512-83500002 +8615195660023 |
sales@senfeida.com | China | 23048 | 58 |
LEAPCHEM CO., LTD. | +86-852-30606658 |
market18@leapchem.com | China | 43348 | 58 |
Beijing HuaMeiHuLiBiological Chemical | 010-56205725 |
waley188@sohu.com | China | 12338 | 58 |
Shandong Xiya Chemical Co., Ltd. | 4009903999 13395398332 |
sales@xiyashiji.com | China | 20807 | 60 |
Raw material medicin reagent co.,Ltd | |
sales@njromanme.com | China | 4531 | 58 |
Lynnchem | 86-(0)29-85992781 17792393971 |
info@lynnchem.com | China | 4587 | 58 |
블레스티시딘-에스 관련 검색:
클로로타로닐 디티아논 도데실벤젠 설파믹산 도데실벤젠 블레스티시딘-에스
DODECYLBENZENE
H-BETA-ALA-BETA-ALA-OH
Demethylblasticidin S
BLASTICIDIN S HCL,BLASTICIDIN S, HYDROCHLORIDE, STREPTOMYCES GRISEOCHROMOGENES,BLASTICIDIN S HYDROCHLORIDE
Blasticidin H
blasticidin A
blasticidin S deaminase
BLASTICIDIN S HCL UN2811-
blasticidin S-acetyltransferase
Blasticidin S, HCl, Streptomyces griseochromogenes
Blasticidin S sodium salt
BLASTICIDIN S HCL,BLASTICIDIN S HYDROCHLORIDE,BLASTICIDIN S, HYDROCHLORIDE, STREPTOMYCES GRISEOCHROMOGENES,Blasticidin S benzylaminobenzenesulfonate