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펜콘(--)

펜콘(--) 구조식 이미지

카스 번호:: 7787-20-4

한글명:: 펜콘(--)

동의어(한글):: 펜콘(--);L-펜콘

상품명:: (-)-FENCHONE

동의어(영문):: L-FENCHONE;(-)-FENCHONE;L(-)-FENCHONE;FENCHONE, (-)-;ALPHA-FENCHONE;laevo-fenchone;(-)-Fenchone>L-ALPHA-FENCHONE;(1R,4S)-fenchone;L-FENCHONE 98+%

CBNumber:: CB2283113

분자식:: C10H16O

포뮬러 무게:: 152.23

MOL 파일:: 7787-20-4.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 164

펜콘(--) 속성

녹는점: 5-6 °C(lit.)

끓는 점: 192-194 °C(lit.)

알파: [α]D20 -50～-60° (c=4, C2H5OH)

밀도: 0.948 g/mL at 25 °C(lit.)

증기압: 2.149hPa at 20℃

FEMA: 4519 | L-FENCHONE

굴절률: n20/D 1.461(lit.)

인화점: 127 °F

저장 조건: 2-8°C

용해도: 클로로포름(약간 용해됨), 에탄올(약간 용해됨, 초음파처리)

물리적 상태: 액체

색상: 무색투명~연황색

냄새: 100.00%에서. 장뇌 허브 흙 같은 우디

?? ??: 녹나무 같은

optical activity: [α]24/D 50.5°, neat

수용성: 1.983g/L at 20℃

JECFA Number: 2200

BRN: 2042710

Dielectric constant: 12.0（20℃）

LogP: 2.54 at 20℃

CAS 데이터베이스: 7787-20-4(CAS DataBase Reference)

EPA: Bicyclo[2.2.1]heptan-2-one, 1,3,3-trimethyl-, (1R,4S)- (7787-20-4)

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

위험 카페고리 넘버	10
안전지침서	23-24/25
유엔번호(UN No.)	UN 1224 3/PG 3
WGK 독일	3
RTECS 번호	RB7875000
TSCA	Yes
위험 등급	3
포장분류	III
HS 번호	29142900
독성	The acute oral LD₅₀ value in rats was reported as 616 g/kg (Jenner, Hagan, Taylor. Cook & Fitzhugh, 1964) and the acute dermal LD₅₀ value in rabbits exceeded 5 g/kg (Leven-stein, 1975).

그림문자(GHS):

신호 어:

Warning

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	그림 문자	P- 코드
H411	장기적 영향에 의해 수생생물에 유독함	수생 환경유해성 물질 - 만성	구분 2

예방조치문구:

P273	환경으로 배출하지 마시오.
P391	누출물을 모으시오.
P501	...에 내용물 / 용기를 폐기 하시오.

NFPA 704

	2
0		0

펜콘(--) C화학적 특성, 용도, 생산

화학적 성질

CLEAR COLOURLESS TO SLIGHTLY YELLOW LIQUID

출처

Reported to be found in many essential oils, including those of Thuja plicata, T.occiden-talis, T.standi shii, Russian anise, fennel, a few Artemisia varieties (A. frigida, A . verlotorum and A . santolinaefolia), Lavandula stoechas and L. burmannii. The highest levels (12-19%) are found in fennel oil (Fenarolis Handbook of Flavor Ingredients, 1975; Gildemeister & Hoffman, 1963).

용도

(1R,?4S)?-1,?3,?3-?Trimethylbicyclo[2.2.1]?heptan-?2-?one also known more commonly as (-)-Fenchone is a chiral intermediate of Fenchone and is currently being used for studies ranging from inhibitory effects of monoterpenes on human TRPA1 and odorant receptor of the malaria vector Anopheles gambiae.

제조 방법

By isolation from cedar leaf oil (Thuja oil) or by various synthetic methods (Arctander, 1969).

정의

ChEBI: A fenchone that has (1R,4S)-stereochemistry. It is a constituent of the essential oils obtained from fennel.

일반 설명

(1R)-(-)-Fenchone is a bridged bicyclic ketone found in fennel oil and thuja oil.

Pharmacology

In mice, fenchone injected sc in sesame oil produced clonic convulsions at non-lethal doses, with a median convulsive dose (CD₅₀) of 1133 mg/kg, and a dose of 500 mg/kg given sc was an effective arousal agent, reducing the hexobarbitone sleep time (Wenzel & Ross, 1957). In rats, an ip dose of 500 mg/kg had no effect on pentobarbitone-depressed respiration, while ip doses of 50-400 mg/kg increased running activity but did not affect total activity (Wenzel & Ross, 1957). Fenchone showed some antispasmodic action on excised mouse intestine (Haginiwa, Harada & Morishita, 1963), and at 260 mmol/kg showed good choleretic properties of moderately long duration when given orally in olive oil to rats (M?rsdorf, 1966). Thomas (1958) reported that it acted as a central nervous system stimulant. Fenchone has been used medically as a counter-irritant (Merck Index, 1968).

신진 대사

Rimini (1901 & 1909) showed that, in the dog, fenchone was probably oxidized to 4-hydroxyfenchone. Reinartz & Zanke (1936) showed that there were other products. They separated, as lead salts, the glucuronides from the urine of dogs receiving d-fenchone. The lead was removed with sulphuric acid and the resulting solution was hydrolysed. In the resulting mixture of hydroxyfen chones, the presence of 4- and 5-hydroxyfenchones and 7r-apofenchone-3-carboxylic acid was demon strated (Williams, 1959).

Purification Methods

Purification is as for the (+)-enantiomer above and should have the same physical properties except for opposite optical rotations. UV has max 285nm ( 12.29). [Braun & Jacob Chem Ber 66 1461 1933, UV: Ohloff et al. Chem Ber 90 106 1957.] [Beilstein 7 III 392, 7 IV 212.]

펜콘(--) 준비 용품 및 원자재

원자재

아니스의 기름 Bicyclo[2.2.1]heptane-2-selone, 1,3,3-trimethyl-, (1R,4S)- Bicyclo[2.2.1]heptan-2-one, 1,3,3-trimethyl-, oxime, (1R,4S)- methyl 3-(tert-butyldimethylsilyloxy)benzoate (+)-Fenchol Methyl 3-hydroxybenzoate Methyl 3-methoxybenzoate

준비 용품

펜콘(--) 공급 업체

글로벌( 164)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12456	58
Shanghai Zheyan Biotech Co., Ltd.	18017610038	zheyansh@163.com	CHINA	3620	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Hebei Guanlang Biotechnology Co., Ltd.	+86-19930503282	alice@crovellbio.com	China	8823	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
Shanghai Standard Technology Co., Ltd.	18502101150	ft-sales@nature-standard.com	CHINA	1923	58
Wuhan ChemNorm Biotech Co.,Ltd.	+86-27-8439 4403 18971486879	sales@chemnorm.com	CHINA	2935	58
Hubei Ipure Biology Co., Ltd	+8613367258412	ada@ipurechemical.com	China	10326	58
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418671	sales@tnjchem.com	China	34572	58

펜콘(--) 관련 검색:

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