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RO 15-4513

RO 15-4513 구조식 이미지

카스 번호:: 91917-65-6

상품명:: RO 15-4513

동의어(영문):: RO 15-4513;Azidomazenil;Ro15 4513,Ro154513,Ro-15-4513;RO 15-4513 ETHANOL ANTAGONIST;Ethyl-8-azido-5,6-dihydro-5-methyl-6-oxo-4H-imidazo-1,4-benzodiazepine-3-carboxylate;ETHYL 8-AZIDO-6-DIHYDRO-5-METHYL-6-OXO-4H-IMIDAZO[1,5-A]-[1,4]BENZODIAZEPINE-3-CARBOXYLATE;8-Azido-5,6-dihydro-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid ethyl ester;4H-Imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid, 8-azido-5,6-dihydro-6-oxo-, ethyl ester;8-AZIDO-5,6-DIHYDRO-5-METHYL-6-OXO-4H-IMIDAZO[1,5-A][1,4]BENZODIAZEPINE-3-CARBOXYLIC ACID ETHYL ESTER;4H-Imidazo(1,5-A)(1,4)benzodiazepine-3-carboxylic acid, 8-azido-5,6-dihydro-5-methyl-6-oxo-, ethyl ester

CBNumber:: CB2312745

분자식:: C15H14N6O3

포뮬러 무게:: 326.32

MOL 파일:: 91917-65-6.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 40

RO 15-4513 속성

저장 조건: Desiccate at +4°C

용해도: 45%(w/v) 수성 2-히드록시프로필-β-시클로덱스트린: 0.8mg/mL

물리적 상태: 고체

물리적 상태: 단단한 모양

색상: 갈색을 띤 노란색

CAS 데이터베이스: 91917-65-6

안전

WGK 독일	3

RO 15-4513 C화학적 특성, 용도, 생산

개요

Ro 15-4513 is a partial inverse agonist of benzodiazepine receptors. It acts as a competitive antagonist, and can therefore be an antidote to the acute impairment caused by alcohol. Ro 15-4513's Ki values are 3.1 and 5.3 nM for diazepam-insensitive (DI) and diazepam-sensitive (DS) benzodiazepine receptors respectively. Ro 15-4513 displays partial agonism at DI α4- and α6-GABAA receptors.

화학적 성질

Off-white solid

용도

Ro 15-4513 has been used as a benzodiazepine (Bz) inverse agonist in rats and to test its binding with diazepam-sensitive (DS) receptors in in vitro radioligand binding studies.

주요 응용

Ro 15-4513 is benzodiazepine receptor partial inverse agonist. It elicits anxiogenic property and is an ethanol antagonist. It elicits a high affinity towards diazepam sensitive and insensitive sites in the cerebellar region. Ro 15-4513 possesses an imidazo ring and is an imidazobenzodiazepine.

생물학적 활성

High affinity benzodiazepine ligand. K i values are 3.1 and 5.3 nM for diazepam-insensitive (DI) and diazepam-sensitive (DS) benzodiazepine receptors respectively. Acts as partial inverse agonist at recombinant DS α 1-, α 2-, α 3- and α 5-GABA A receptors. Displays partial agonism at DI α 4- and α 6-GABA A receptors. Antagonizes several behavioral and neurochemical effects of ethanol. Proconvulsant and anxiogenic.

RO 15-4513 준비 용품 및 원자재

원자재

준비 용품

RO 15-4513 공급 업체

글로벌( 40)공급 업체

공급자	전화	이메일	국가	제품 수	이점
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8474	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15848	69
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80
EMMX Biotechnology LLC	888-539-0666	info@emmx.com	United States	8449	60
DC Chemicals	021-58447131 13564518121	sales@dcchemicals.com	China	9414	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58
MedBioPharmaceutical Technology Inc	021-69568360 18916172912	order@med-bio.cn	China	8141	58
Beijing Jin Ming Biotechnology Co., Ltd.	010-60605840 15801484223	psaitong@jm-bio.com	China	29834	58

RO 15-4513 관련 검색:

4-이미다졸카르복시산 4-이미다졸메탄올염화수소산염 4(5)-(히드록시메틸)이미다졸 4-(1H-이미다졸-1-일)아닐린 5-Methyl-1H-imidazole-4-carbaldehyde 1-Methyl-1H-imidazole-4-carboxylic acid (1-METHYL-1H-IMIDAZOL-4-YL)METHANOL 1-METHYL-1H-IMIDAZOLE-4-CARBOXYLIC ACID METHYL ESTER ETHYL 5-METHYL-1H-IMIDAZOLE-4-CARBOXYLATE 3-AMINO-N,N-DIMETHYLBENZYLAMINE 4,5-DIMETHYL-1H-IMIDAZOLE Ethyl imidazole-4-carboxylate Methyl 4-imidazolecarboxylate 4-(4-Methyl-1H-imidazol-1-yl)benzenamine 1-(1H-IMIDAZOL-2-YL)-ETHANOL 1,5-DIMETHYL-1H-IMIDAZOLE-4-CARBALDEHYDE 3-AMINO-N-ETHYLBENZAMIDE 3-AMINO-N,N-DIMETHYLBENZAMIDE