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ARN14988

ARN14988 구조식 이미지

카스 번호:: 1502027-70-4

상품명:: ARN14988

동의어(영문):: ARN398;ARN14988;ARN14988,ARN-14988;5-chloro-3-[(hexylamino)carbonyl]-3,6-dihydro-2,6-dioxo-1(2H)-pyrimidinecarboxylicacid,2-methylpropylester;1(2H)-Pyrimidinecarboxylic acid, 5-chloro-3-[(hexylamino)carbonyl]-3,6-dihydro-2,6-dioxo-, 2-methylpropyl ester

CBNumber:: CB24814340

분자식:: C16H24ClN3O5

포뮬러 무게:: 373.83

MOL 파일:: 1502027-70-4.mol

속성

안전

용도

공급 업체 8

ARN14988 속성

밀도: 1.27±0.1 g/cm3(Predicted)

저장 조건: Store at -20°C

용해도: DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml; Ethanol: slightly soluble

물리적 상태: 결정성 고체

산도 계수 (pKa): 7.89±0.40(Predicted)

안전

ARN14988 C화학적 특성, 용도, 생산

개요

ARN14988 is a potent inhibitor of acid ceramidase (IC₅₀ = 12.8 nM for the human enzyme). It inhibits acid ceramidase activity and increases levels of C16 dihydro ceramide and C16 ceramide in A375, G361, M14, MeWo, MNT-1, and SK-MEL-28 melanoma cells. ARN14988 also reduces growth of A375 and G361 melanoma cells (EC₅₀s = 41.8 and 67.7 μM, respectively).

효소 저해제

These sphingolipid-signaling inhibitors (FWARN398 = 307.27 g/mol; FWARN14988 = 373.83 g/mol) target human acid ceramidase, with IC50 values of 7.7 and 12.8 nM, respectively, thereby increasing cellular ceramide levels and decreasing sphingosine 1-phosphate, and synergizing with several antitumor agents. Compared to normal melanocytes, ceramide production is suppressed in melanoma cells, and elevation of ceramide levels enhances the cytotoxic effects of chemotherapeutic drugs on proliferative melanoma cells in culture. ARN398 is unstable, showing a plasma half-life of 1 min and an in vitro half-life of 120 min at pH 4.5. ARN398 is more stable, showing a plasma half-life of 300 min and an in vitro half-life of 140 min at pH 4.5.

ARN14988 준비 용품 및 원자재

원자재

준비 용품

ARN14988 공급 업체

글로벌( 8)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9709	58
Shanghai Hongye Biotechnology Co. Ltd	400-9205774	sales@glpbio.cn	China	6870	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58
Changzhou Furuisi Biotechnology Co., Ltd	0519-85524369	3477467573@qq.com	China	8618	58
Beijing Biocreative Technology Co., Ltd.	15522676233	3007606172@qq.com	China	1249	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24023	58
Nanjing Tengyi Biotechnology Co., Ltd	025-58851786 17714337195	sales@tybiochem.com	China	5060	58