Dimetotiazine

Dimetotiazine C화학적 특성, 용도, 생산

Originator

Migristene,Rhone Poulenc,France,1965

용도

Serotonin inhibitor.

Manufacturing Process

A solution of 3-dimethylsulfamoylphenthiazine (10 grams) in xylene (100 cc) is heated under reflux for 3 hours with sodium amide (1.5 grams). A solution of 1-dimethylamino-2-chloropropane (4.4 grams) in anhydrous xylene (30 cc) is then added and heating under reflux continued for 4 hours. After cooling the suspension obtained is agitated with water (50 cc) and ether (30 cc). The aqueous layer is separated and the basic products are extracted from the organic phase with 10% hydrochloric acid. The xylene layer is discarded and, after the combined acid solutions have been made alkaline with sodium carbonate, the base is extracted with chloroform. The chloroform solutions are then washed with water and dried over anhydrous potassium carbonate. After evaporation of the solvent under reduced pressure there is obtained a crude resinous base (9.7 grams).
On the addition of ethereal hydrogen chloride to a solution of the base in isopropanol and recrystallization from anhydrous ethanol of the salt formed, there is obtained 3-dimethylsulfamoyl-10-(2-dimethylaminopropyl) phenthiazine hydrochloride (2.1 grams), MP 214°C with decomposition. After dissolving the product in anhydrous ethanol and adding methanesulfonic acid there is obtained fonazine mesylate.

Dimetotiazine 준비 용품 및 원자재

원자재

준비 용품

Dimetotiazine 공급 업체

공급자	전화	이메일	국가	제품 수	이점
LGM Pharma	1-(800)-881-8210	inquiries@lgmpharma.com	United States	2110	70
BOC Sciences	16314854226; +8616314854226	inquiry@bocsci.com	United States	19852	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569262 +86-15003564040	1056@dideu.com	China	3969	58
Shaanxi Dideu Medichem Co. Ltd	+86-17392712779	1097@dideu.com	China	3989	58
Aribo Pharmatech Co., Ltd.	19951442182	sales@aribopharm.com	China	1775	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	29873	58
DAYANG CHEM (HANGZHOU) CO.,LTD	+86-88938639 +86-17705817739	info@dycnchem.com	China	53586	58
TargetMol Chemicals Inc.	13564774135	marketing@targetmol.com	United States	19950	58
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com	United States	38999	58

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