UCN-01
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UCN-01 속성
- 끓는 점
- 705.7±60.0 °C(Predicted)
- 밀도
- 1.63±0.1 g/cm3(Predicted)
- 저장 조건
- 2-8°C
- 용해도
- 에 용해됨 DMSO: >5mg/mL
- 물리적 상태
- 황갈색 고체
- 산도 계수 (pKa)
- 12.25±0.70(Predicted)
- 색상
- 연노랑
- optical activity
- [α]20/D 130 to 160°, c = 0.2 in DMSO
안전
WGK 독일 | 3 | ||
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RTECS 번호 | KC6600010 | ||
독성 | mouse,LD50,intraperitoneal,25mg/kg (25mg/kg),Journal of Antibiotics. Vol. 42, Pg. 571, 1989. |
UCN-01 C화학적 특성, 용도, 생산
개요
UCN-01 is a synthetic derivative of staurosporine with antiproliferative activity against several in vitro and in vivo cancer models. It inhibits a variety of kinases, including Akt, protein kinase C (IC50 = 30 nM), PDK1 (IC50 = 6 nM) and cyclin-dependent kinases (IC50s = 300-600 nM for Cdk1 and Cdk2). UCN-01 arrests tumor cells in the G1/S phase of the cell cycle and prevents nucleotide excision repair by inhibiting the G2 checkpoint kinase Chk1 (IC50 = 7 nM), leading to apoptosis.용도
UCN-01 is an indolocarbazole isolated from a high staurosporine-producing Streptomyces culture. UCN-01 inhibits protein kinase C (PKC) and cyclin-dependant kinase 2 (CDK2), resulting in accumulation of cells in the G1 phase and induction of apoptosis. UCN-01 also enhances the cytotoxicity of other anti-cancer drugs, such as DNA-damaging agents and anti-metabolite drugs, through putative abrogation of G2 and/or S phase accumulation induced by the latter agents.일반 설명
A cell-permeable Staurosporine (Cat. No. 569397) derived anticancer agent that reversibly and ATP-competitively inhibits several protein kinases (IC50 = 29 nM, 34 nM, 30 nM, 590 nM and 530 nM for PKCα, PKCβ, PKCγ, PKCδ and PKCε; IC50 = 7 nM, 27 nM, 50 nM, 50 nM, 150 nM and 1.04 M for Chk1, Cdc25C-associated protein kinase 1, Cdk1, PAK4, Cdk5/p25 and Chk2; IC50 = 33 nM, 50 nM, 95 nM, 500 nM, 500 nM and 1.0 M for PDK1, lck, MAPKAP kinase-2, Akt, GSK-3β and PKA, respectively). At higher concentrations (>15 M), affects the activities of Src, PIM-1, CKII, DNA-PK, ErK1, ILK-1 and MAPKK1). Reported to suppress thymidylate synthase expression, induce apoptosis with caspase activation, and sensitize tumor cells to a range of DNA-damaging agents.UCN-01 준비 용품 및 원자재
원자재
준비 용품
UCN-01 공급 업체
글로벌( 54)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
Career Henan Chemica Co | +86-0371-86658258 15093356674; |
laboratory@coreychem.com | China | 30255 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 |
sales@hzclap.com | CHINA | 6313 | 58 |
Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 |
sales@molcore.com | China | 49739 | 58 |
Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 |
info@chemextension.com | China | 42057 | 58 |
Aladdin Scientific | +1-833-552-7181 |
sales@aladdinsci.com | United States | 57511 | 58 |
Nanjing Chemlin Chemical Co., Ltd | 025-83697070 |
info@chemlin.com.cn | China | 17988 | 64 |
BOC Sciences | 1-631-485-4226; 16314854226 |
info@bocsci.com | United States | 14059 | 65 |
Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 18521732826; |
market@aladdin-e.com | China | 25015 | 65 |
ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 |
sales-cpd@caerulumpharma.com | China | 3420 | 58 |
UCN-01 관련 검색:
아세틸아세톤산 구리 디스프로슘 트리(2,2,6,6-테트라메틸-3,5-헵탄디오네이트) 아세틸아세토산 제2철 코발트(II) 아세틸아세토네이트 하이드레이트 알루미늄 아세틸아세토네이트 실버 아세틸아세토네이트
1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE
DICHLORO(ETHYLENEDIAMINE)PLATINUM(II)
METHYL ISOCYANOACETATE
SALCOMINE
Tris(2,4-pentanedionato)chroMiuM(III)
N-BUTYLISOCYANIDE
TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III)
PHENYLSELENOL
Benzyl isocyanide
Tosylmethyl isocyanide
Ethyl isocyanoacetate
TERT-BUTYL ISOCYANIDE