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5,12-dihydroquinoxalino[2,3-b]quinoxaline

5,12-dihydroquinoxalino[2,3-b]quinoxaline 구조식 이미지

카스 번호:: 531-46-4

상품명:: 5,12-dihydroquinoxalino[2,3-b]quinoxaline

동의어(영문):: ML-090;Fluoflavine;5,12-dihydroquinoxalino[2,3-b]quinoxaline;6,11-dihydroquinoxalino[2,3-b]quinoxaline;Quinoxalino[2,3-b]quinoxaline, 5,11-dihydro-;5,12-Dihydroquinoxalino[2,3-b]quinoxaline (~90%);NOX4,ML090,NADPH Oxidase,Inhibitor,NOX,HEK293 cell,NOX3,ML 090,NOX2,inhibit,ML-090,NOX1

CBNumber:: CB31549066

분자식:: C14H10N4

포뮬러 무게:: 234.26

MOL 파일:: 531-46-4.mol

속성

안전

용도

공급 업체 17

5,12-dihydroquinoxalino[2,3-b]quinoxaline 속성

녹는점: >262°C (dec.)

끓는 점: 450.2±28.0 °C(Predicted)

밀도: 1.43±0.1 g/cm3(Predicted)

저장 조건: -20°C Freezer

용해도: DMSO(약간 가열, 초음파 처리)에 용해됨

물리적 상태: 고체

물리적 상태: 단단한 모양

산도 계수 (pKa): 3.94±0.20(Predicted)

색상: 미색에서 진한 노란색까지

InChI: InChI=1S/C14H10N4/c1-2-6-10-9(5-1)15-13-14(16-10)18-12-8-4-3-7-11(12)17-13/h1-8H,(H,15,17)(H,16,18)

InChIKey: WGKYYZDYHYOKQV-UHFFFAOYSA-N

SMILES: N1C2=C(C=CC=C2)N=C2NC3=C(N=C12)C=CC=C3

안전

5,12-dihydroquinoxalino[2,3-b]quinoxaline C화학적 특성, 용도, 생산

개요

NADPH oxidase 1 (NOX1) generates reactive oxygen species (ROS) in colon epithelial cells that interacts with both pathogenic and normal bacteria. Excess ROS production, however, is associated with damage to the intestinal mucosa, inflammatory bowel disease, and prostate cancer. ML-090 is the first identified NOX1-specific inhibitor (IC₅₀ = 360 nM in HEK293 cells) based on a quinoxaline scaffold that demonstrates potent selectivity over NOX2, NOX3, and NOX4 (IC₅₀s ≥ 10 μM) and xanthine oxidase (IC₅₀ = 3.5 μM).

용도

5,12-Dihydroquinoxalino[2,3-b]quinoxaline is an inhibitor of?NADPH oxidase 1 (NOX1).

5,12-dihydroquinoxalino[2,3-b]quinoxaline 준비 용품 및 원자재

원자재

준비 용품

5,12-dihydroquinoxalino[2,3-b]quinoxaline 공급 업체

글로벌( 17)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	+86-18341751992 +86-15382112998	757984502@qq.com	China	892	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9709	58
Shanghai TenSus Biotechnology Co., Ltd.	021-50895067 18616507272	tensus@163.com	China	4207	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58
MedBioPharmaceutical Technology Inc	021-69568360 18916172912	order@med-bio.cn	China	8141	58
Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd	0431-80514535 19917294565	caoy@chemextension.com	China	2724	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24131	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	024-024-88590548 18341751992	757984502@qq.com	China	888	58