(S)-CR8
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(S)-CR8 속성
- 끓는 점
- 671.4±65.0 °C(Predicted)
- 밀도
- 1.27±0.1 g/cm3(Predicted)
- 저장 조건
- +2C to +8C
- 용해도
- DMSO: soluble,Ethanol: soluble
- 물리적 상태
- 회백색 고체
- 산도 계수 (pKa)
- 14.56±0.10(Predicted)
(S)-CR8 C화학적 특성, 용도, 생산
개요
(S)-CR8 is a second generation derivative of (R)-roscovitine and an inhibitor of cyclin-dependent kinase 1 (Cdk1/cyclin B), Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p25, and Cdk9/cyclin T (IC50s = 0.15, 0.08, 0.06, 0.12, and 0.11 μM, respectively). It also inhibits casein kinase CK1δ/ε (CKδ/ε) and DYRK1A (IC50s = 0.61 and 0.9 μM, respectively). (S)-CR8 reduces cell viability in human neuroblastoma cell lines, including SH-SY5Y, SK-N-AS, SK-N-BE, and IMR32 cells (IC50s = 0.43, 1.46, 0.13, and 0.14 μM, respectively). It also reduces protein levels of the survival factor Mcl-1 in SH-SY5Y cells.(S)-CR8 준비 용품 및 원자재
원자재
준비 용품
(S)-CR8 공급 업체
글로벌( 13)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32480 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
| Aladdin Scientific | +1-833-552-7181 |
sales@aladdinsci.com | United States | 52927 | 58 |
| Hubei Chuangliankangcheng Pharmaceutical Co., Ltd. | 027-65388397 18164111589 |
3321478047@qq.com | China | 1991 | 55 |
| ATK CHEMICAL COMPANY LIMITED | 3429815786 13301662590 |
sales@atkchemical.com | China | 10007 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 |
info@efebio.com | China | 9709 | 58 |
| Shanghai SuperLan Chemcial Technique Centre | 021-2022843681 15618226720 |
chaolaichem@foxmail.com | China | 6870 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 |
sales@chemegen.com | China | 11289 | 58 |
| JinOu Biomedical (Nanjing) Co., Ltd. | 13000000000 |
jinoupharma@163.com | China | 11732 | 58 |
| Changzhou Bojia Biomedical Technology Co., Ltd. | 2122619822 |
czbjpharma@126.com | China | 18488 | 58 |