MMP-2/MMP-9 Inhibitor V - CAS 869577-53-7 - Calbiochem 속성
끓는 점
614.6±65.0 °C(Predicted)
밀도
1.474±0.06 g/cm3(Predicted)
산도 계수 (pKa)
8.13±0.10(Predicted)
안전
MMP-2/MMP-9 Inhibitor V - CAS 869577-53-7 - Calbiochem C화학적 특성, 용도, 생산
일반 설명
A cell-permeable sulfonamido analog of SB-3CT (Cat. No. 444274) that displays enhanced aqueous solubility and improved selectivity (Ki = 16 nM, 180 nM, and 900 nM for MMP-2, MMP-9, and MMP-14, respectively). Inhibits MMP-3, MMP-7, and MMP-1 only at much higher concentrations (Ki = 3.6 μM, 295 μM, and >25 μM, respectively). Binds to the enzyme active site and acts as an irreversible inhibitor. Reported to potently suppress cell migration and invasion of HT1080 cells (80% inhibition at 2 μM and >25% inhibition at 100 nM, respectively). Unlike the general MMP inhibitor GM6001 (Cat. No. 364205), this inhibitor does not block the activation of cellular pro-MMP-2 by MT1-MMP.
Biochem/physiol Actions
Cell permeable: yes
MMP-2/MMP-9 Inhibitor V - CAS 869577-53-7 - Calbiochem 준비 용품 및 원자재
원자재
준비 용품
MMP-2/MMP-9 Inhibitor V - CAS 869577-53-7 - Calbiochem 공급 업체
