InSolution p38 MAP Kinase Inhibitor III - Calbiochem

InSolution p38 MAP Kinase Inhibitor III - Calbiochem C화학적 특성, 용도, 생산

일반 설명

A cell-permeable, potent, selective, and ATP-competitive inhibitor of p38 MAP kinase (IC₅₀ = 380 nM for p38α). Shown to effectively suppress LPS-induced cytokine release in vitro (IC₅₀ = 160 nM for TNF-α release and 39 nM for IL-1β release, human PBMC) and in vivo (ED₅₀ = 1.33 mg/kg for TNF-α release in mice). Exhibits reduced inhibitory activity against cytochrome P450-2D6 compared to SB 203580 (Cat. No 559389) and is better suited for use in animal models.

Biochem/physiol Actions

Cell permeable: yes

InSolution p38 MAP Kinase Inhibitor III - Calbiochem 준비 용품 및 원자재

원자재

준비 용품

InSolution p38 MAP Kinase Inhibitor III - Calbiochem 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80