RP-8-브로모-베타-페닐-1,N2-에테노구아노신3',5'-환상모노포스포로티오에이트나트륨염수화물
|
|
RP-8-브로모-베타-페닐-1,N2-에테노구아노신3',5'-환상모노포스포로티오에이트나트륨염수화물 속성
- 녹는점
- 240-300 °C(lit.)
- 저장 조건
- -20°C
- 용해도
- H2O: 60°C 이하에서 용해성 15mg/mL
- 물리적 상태
- 가루
- 색상
- 흰색에서 베이지색
안전
안전지침서 | 22-24/25 | ||
---|---|---|---|
WGK 독일 | 3 |
RP-8-브로모-베타-페닐-1,N2-에테노구아노신3',5'-환상모노포스포로티오에이트나트륨염수화물 C화학적 특성, 용도, 생산
개요
Rp-8-bromo-PET-Cyclic GMPS (Rp-8-bromo-PET-cGMPS) is an analog of cyclic GMP (cGMP). It is a cell permeable, competitive, and reversible inhibitor of cGMP-dependent protein kinases (cGKs) that blocks activation of cGKI and cGKII by cGMP (Kis = 35 and 30 nM). It less potently inhibits protein kinase A (Ki = 11 μM) and cGMP-induced activation of cyclic nucleotide-gated channels (IC50 = 25 μM). In the absence of cGMP stimulation, Rp-8-bromo-PET-cGMPS can act as a partial agonist of cGKI (Ki = 1 μM). Rp-8-bromo-PET-cGMPS is resistant to hydrolysis by phosphodiesterase 11.용도
Rp-8-Br-PET-cyclic GMPS Sodium Salt is a competitive inhibitor of cGMP-dependent protein kinase (cGKI).Biochem/physiol Actions
Rp-8-Br-PET-cGMPS is metabolically stable, competitive inhibitor of cGMP-dependent protein kinase G. Inhibits both PKG I (Ki?=?30 nM) and PKG II and blocks cGMP-gated retinal type ion channels (IC50?=?25 micromoles).RP-8-브로모-베타-페닐-1,N2-에테노구아노신3',5'-환상모노포스포로티오에이트나트륨염수화물 준비 용품 및 원자재
원자재
준비 용품
RP-8-브로모-베타-페닐-1,N2-에테노구아노신3',5'-환상모노포스포로티오에이트나트륨염수화물 공급 업체
글로벌( 22)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 |
sales@aladdinsci.com | United States | 52927 | 58 |
Sigma-Aldrich | 021-61415566 800-8193336 |
orderCN@merckgroup.com | China | 51471 | 80 |
EMMX Biotechnology LLC | 888-539-0666 |
info@emmx.com | United States | 8449 | 60 |
Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 |
info@efebio.com | China | 9707 | 58 |
BOC Sciences | -- |
info@bocsci.com | USA | 0 | 65 |
ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 |
sales@chemegen.com | China | 11289 | 58 |
Energy Chemical | 021-58432009 400-005-6266 |
marketing1@energy-chemical.com | China | 44843 | 58 |
MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 |
order@med-bio.cn | China | 8141 | 58 |
Changzhou Furuisi Biotechnology Co., Ltd | 0519-85524369 |
3477467573@qq.com | China | 8618 | 58 |