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L-아스코르빈산팔미틴산에스테르

L-아스코르빈산팔미틴산에스테르
L-아스코르빈산팔미틴산에스테르 구조식 이미지
카스 번호:
137-66-6
한글명:
L-아스코르빈산팔미틴산에스테르
동의어(한글):
L-아스코르빈산팔미틴산에스테르;아스코르브산,6-아스코르브산;아스코르브산,6-아스코르브산;아스코빌팔미테이트
상품명:
Ascorbyl Palmitate
동의어(영문):
E304;LGB-AP;scorbic;ascorbyl;quicifal;ondascora;NSC 402451;Ascorbyl palMi;cetylascorbate;scorbicpalmitate
CBNumber:
CB4121121
분자식:
C22H38O7
포뮬러 무게:
414.53
MOL 파일:
137-66-6.mol

L-아스코르빈산팔미틴산에스테르 속성

녹는점
115-118 °C(lit.)
알파
+21~+26°(20℃/D, c=2, C2H5OH)
끓는 점
512.7±50.0 °C(Predicted)
밀도
1.150±0.06 g/cm3(Predicted)
굴절률
22.5 ° (C=1, EtOH)
저장 조건
2-8°C
용해도
Slightly soluble in ethyl alcohol.
물리적 상태
neat
산도 계수 (pKa)
3.96±0.10(Predicted)
optical activity
[α]20/D +23±1°, c = 1% in ethanol
BRN
96552
InChIKey
QAQJMLQRFWZOBN-UWJYYQICSA-N
CAS 데이터베이스
137-66-6(CAS DataBase Reference)
EPA
Ascorbyl palmitate (137-66-6)

안전

위험품 표기 Xn
위험 카페고리 넘버 20/21/22-36/37/38
안전지침서 26-36-24/25
WGK 독일 1
RTECS 번호 CI7671040
TSCA Yes
HS 번호 2936 27 00
유해 물질 데이터 137-66-6(Hazardous Substances Data)
독성 LD50 orally in Rabbit: > 5000 mg/kg
기존화학 물질 KE-01949

L-아스코르빈산팔미틴산에스테르 C화학적 특성, 용도, 생산

개요

Ascorbyl palmitate is a lipophilic derivative of ascorbic acid (Item No. 14656) with antioxidant and antiproliferative activities. It scavenges hydroxyl radicals in cell-free assays. Ascorbyl palmitate (0.01%) reduces the rate of autoxidation of soybean, safflower, sunflower, peanut, and corn oil. It inhibits increases in epidermal ornithine decarboxylase activity and DNA synthesis induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in mice in a concentration-dependent manner when applied topically. Ascorbyl palmitate (0.8 and 4 μmol per 200 μl of acetone, applied topically) reduces the number of tumors per mouse and the percentage of mice with tumors in a mouse skin two-stage model of tumor formation initiated and promoted by 7,12-dimethylbenz[a]anthracene (DMBA) and TPA, respectively. Formulations containing ascorbyl palmitate have been used as antioxidants and preservatives in foods, pharmaceuticals, and cosmetics.

화학적 성질

Light yellow powder

화학적 성질

Ascorbyl palmitate is a practically odorless, white to yellowish powder.

용도

Ascorbyl Palmitate is an ester formed from ascorbic acid (A786990) and palmitic acid (P144500) creating a fat soluble form of vitamin C. Ascorbyl Palmitate is also used as an antioxidant food additiv e.

용도

ascorbyl palmitate is used as a preservative and an anti-oxidant in cosmetic creams and lotions to prevent rancidity. Ascorbyl palmitate facilitates the incorporation of ingredients such as vitamins A, C, and D into cosmetic formulations. It has no known toxicity.

용도

Ascorbyl Palmitate is an antioxidant formed by combining ascor- bic acid with palmitic acid. ascorbic acid is not fat soluble but ascor- byl palmitate is, thus combining them produces a fat-soluble antioxidant. it exists as a white or yellowish white powder of citric- like odor. it is used as a preservative for natural oils, edible oils, col- ors, and other substances. it acts synergistically with alpha-tocopherol in oils/fats. it is used in peanut oil at a maximum level of 200 mg/kg individually or in combination.

정의

A white or yellowish-white powder having a citrus-like odor. Mp 116–117C; soluble in alcohol and in animal and vegetable oils; slightly soluble in water.

생산 방법

Ascorbyl palmitate is prepared synthetically by the reaction of ascorbic acid with sulfuric acid followed by reesterification with palmitic acid.

일반 설명

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Ascorbyl Palmitate is a lipophilic ascorbic acid derivative, used as an antioxidant in both food and cosmetics industries.

Pharmaceutical Applications

Ascorbyl palmitate is primarily used either alone or in combination with alpha tocopherol as a stabilizer for oils in oral pharmaceutical formulations and food products; generally 0.05% w/v is used. It may also be used in oral and topical preparations as an antioxidant for drugs unstable to oxygen. The combination of ascorbyl palmitate with alpha tocopherol shows marked synergism, which increases the effect of the components and allows the amount used to be reduced.
The solubility of ascorbyl palmitate in alcohol permits it to be used in nonaqueous and aqueous systems and emulsions.

Biochem/physiol Actions

6-O-Palmitoyl-L-ascorbic acid possesses metastasis inhibitory and anti-tumor activity. Ascorbyl palmitate exhibits antioxidant activity by protecting the cell membranes from oxidative damage.

Safety Profile

When heated to decomposition it emits acrid smoke and irritating fumes.

Safety

Ascorbyl palmitate is used in oral pharmaceutical formulations and food products, and is generally regarded as an essentially nontoxic and nonirritant material. The WHO has set an estimated acceptable daily intake for ascorbyl palmitate at up to 1.25 mg/kg bodyweight.
LD50 (mouse, oral): 25 g/kg
LD50 (rat, oral): 10 g/kg

저장

Ascorbyl palmitate is stable in the dry state, but is gradually oxidized and becomes discolored when exposed to light and high humidity. In an unopened container, stored in a cool place, it has a shelf life of at least 12 months. During processing, temperatures greater than 658℃ should be avoided.
The bulk material should be stored in an airtight container at 8–158℃, protected from light.

비 호환성

Incompatibilities are known with oxidizing agents; e.g. in solution oxidation is catalyzed by trace metal ions such as Cu2+ and Fe3+.

Regulatory Status

GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (oral, rectal, topical preparations). Included in nonparenteral medicines licensed in the UK.

L-아스코르빈산팔미틴산에스테르 준비 용품 및 원자재

원자재

준비 용품


L-아스코르빈산팔미틴산에스테르 공급 업체

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