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비타민 C

비타민 C
비타민 C 구조식 이미지
카스 번호:
50-81-7
한글명:
비타민 C
동의어(한글):
L-릭소아스코르브산;칸탄;테스타스코르빅;(+)-아스코르브산;L-(+)-아스코르브산;L-아스코르빈산;L-아스코빅산;L-크실로아스코르브산;라로스코빈;비타민C;비타신;세비타믹산;세테미칸;아스코부티나;아스코신;안티스코부틱비타민;알레코브;크시틱스;프로스코르빈;아스코빅산
상품명:
L(+)-Ascorbic acid
동의어(영문):
100M;Celin;Cevex;Cewin;Cipca;Vicin;Cebid;Cecon;Hicee;IDO-C
CBNumber:
CB7853704
분자식:
C6H8O6
포뮬러 무게:
176.12
MOL 파일:
50-81-7.mol

비타민 C 속성

녹는점
190-194 °C (dec.)
알파
20.5 º (c=10,H2O)
끓는 점
227.71°C (rough estimate)
밀도
1,65 g/cm3
굴절률
21 ° (C=10, H2O)
FEMA
2109 | ASCORBIC ACID
저장 조건
Store at +5°C to +30°C.
용해도
H2O: 50 mg/mL at 20 °C, clear, nearly colorless
산도 계수 (pKa)
4.04, 11.7(at 25℃)
물리적 상태
powder
색상
white to slightly yellow
수소이온지수(pH)
1.0 - 2.5 (25℃, 176g/L in water)
냄새
Odorless
pH 범위
1 - 2.5
optical activity
[α]25/D 19.0 to 23.0°, c = 10% in H2O
수용성
333 g/L (20 ºC)
Merck
14,830
BRN
84272
안정성
Stable. May be weakly light or air sensitive. Incompatible with oxidizing agents, alkalies, iron, copper.
InChIKey
CIWBSHSKHKDKBQ-JLAZNSOCSA-N
CAS 데이터베이스
50-81-7(CAS DataBase Reference)
NIST
L-Ascorbic acid(50-81-7)
EPA
Ascorbic acid (50-81-7)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기
위험 카페고리 넘버
안전지침서 24/25-36-26
WGK 독일 1
RTECS 번호 CI7650000
TSCA Yes
HS 번호 29362700
유해 물질 데이터 50-81-7(Hazardous Substances Data)
독성 LD50 oral in rat: 11900mg/kg
기존화학 물질 KE-01947
그림문자(GHS):
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H226 인화성 액체 및 증기 인화성 액체 구분 3 경고
H319 눈에 심한 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2A 경고 P264, P280, P305+P351+P338,P337+P313P
예방조치문구:
P210 열·스파크·화염·고열로부터 멀리하시오 - 금연 하시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P370+P378 화재 시 불을 끄기 위해 (Section 5. 폭발, 화재시 대처방법의 적절한 소화제)을(를) 사용하시오.
NFPA 704
1
1 1

비타민 C MSDS


L-Threo-2,3,4,5,6-pentahydroxy-1-hexenoic acid-4-lactone

비타민 C C화학적 특성, 용도, 생산

물성

아스 코르 베이트 음이온에 대한 표준 구조
아스코르브 산은 reductone로 분류되고. 아스 코르 베이트 음이온이 전자의 비편 재화에 의해 안정화, twocanonical 형태 사이의 공진면에 위와 같이. 이러한 이유, 화합물만을 절연 수산기 함유하는 경우 아스코르브 산 훨씬 산성 기대되는 것보다.

개요

수용성 비타민 중 하나로, 아스코브산(ascorbic acid)이라고도 한다. 월터 호어스가 최초로 화학구조를 규명해 노벨화학상을 수상했다. 생물의 에너지 대사과정에서 필수적인 조효소로 작용하며 항산화 작용에도 관여하는 물질이다. 다른 동물들의 경우 체내에서 어느 정도 자체적으로 합성이 가능하나, 사람을 포함한 영장류와 설치류 중 기니피그는 체내의 아스코르브산 합성에 관여하는 효소가 결핍되어 있기 때문에 반드시 외부에서 섭취해야만 한다.

용도

방부제로써도 널리 사용된다. 당장 통조림 같은 가공식품에서 L-아스코르브산나트륨을 찾아보자.

용도

아스 코르 빈산 및 소듐, 칼륨, 칼슘 염은 일반적으로 항산화 식품 첨가물로 사용된다. 이들 화합물은 수용성이고, 그러므로, 산화에서 지방을 보호 할 수 없습니다: 이 목적을 위해, 장쇄 지방산 (아스 코르 빌 팔미 테이트 또는 아스 코르 빌 스테아 레이트)과 아스코르브 산의 에스테르, 지용성 항산화 식품으로 사용될 수있다.

용도

제약 산업 , 의약품에에서는 주로 보충 치료 연습 서로 다른 분야에서 임상적으로 중요 한 자료로 다양 한 의약품을 생산 하 사용할 수 있습니다. 그것은 또한 괴 혈 병 치료에 사용 되며 다양 한 급성 및 만성 감염 질환, VC의 부족에 적용. 식품 산업 에, 그것은 둘 다 사용할 수 영양 알 보충, 식품 가공, 보충 VC 및 좋은 항 산화 식품 보존, 육류 제품, 발효 밀가루 제품, 맥주, 차 dtinks, 과일 주스, 통조림된 과일, 통조림 고기와. 의약품 화장품, 사료 첨가제 및 기타 산업용 영역에에서 일반적으로 사용 됩니다.

개요

Ascorbic acid, a water-soluble dietary supplement, is consumed by humans more than any other supplement. The name ascorbic means antiscurvy and denotes the ability of ascorbic to combat this disease. Vitamin C is the l-enantiomer of ascorbic acid. Ascorbic acid deficiency in humans results in the body’s inability to synthesize collagen, which is the most abundant protein in vertebrates.

화학적 성질

Ascorbic acid occurs as a white to light-yellow-colored, nonhygroscopic, odorless, crystalline powder or colorless crystals with a sharp, acidic taste. It gradually darkens in color upon exposure to light.

화학적 성질

White crystals (plates or needles). Soluble in water; slightly soluble in alcohol; insoluble in ether, chloroform, benzene, petroleum ether, oils and fats. Stable to air when dry. One international unit is equivalent to 0.05 milligram of l-ascorbic acid.

물리적 성질

Appearance: white crystal or crystalline powder, and it is odorless and flavors sour. The color changes yellowish when exposed in the air for a long time. Its aqueous solution is acidic reaction. Solubility: vitamin C is soluble in water, slightly soluble in ethanol, and insoluble in chloroform or ether. Melting point: 190–192? °C.? It would decompose when it melts. Specific optical rotation: +20.5 to +21.5°. Ascorbic acid is two-base acid (the pKa is 4.1 and 11.8). It occurs mainly in the form of sodium salt and calcium salt, and its aqueous solution is strongly acidic reaction. Ascorbic acid is a strong reducing agent.

Originator

Ascorbic aci,Natur Product,France

역사

Vitamin C is a general term for compounds having ascorbic acid activity, including ascorbic acid, dehydroascorbic acid, and its isomers.
The understanding of vitamin C has gone through a long and painful process. Although the relationship between scurvy and stored food is obvious, but the treatments of this disease have been misguided. By 1601, British armed Captain James Lancaster discovered the disease on the ship of the East India Company and regarded the scurvy as “rot,” which could be made tissue alkaline.
At the early stage of the nineteenth century, the understanding and treatment of scurvy had developed to a right approach. The exposition of scurvy etiology and metabolic theory took more than a century.
By the early stage of the twentieth century, inspired by the animal model of beriberi, researchers in the Christchurch Oslo University discovered one animal that could suffer scurvy accidentally and then established a valuable scurvy animal model. This experiment demonstrated that the extract isolated from lemon had antiscurvy activity. Until 1932, many research groups obtained the anti-scurvy crystal from different plants and identified the crystal as ascorbic acid vitamin C. Next year, the chemical structure of ascorbic acid was elucidated, and then its artificial synthesis was accomplished.

용도

antiscorbutic, antiviral

용도

analgesic, antipyretic

용도

Physiological antioxidant. Coenzyme for a number of hydroxylation reactions; required for collagen synthesis. Widely distributed in plants and animals. Inadequate intake results in deficiency syndrome s such as scurvy. Used as antimicrobial and antioxidant in foodstuffs.

용도

vitamin C is a well-known anti-oxidant. Its effect on free-radical formation when topically applied to the skin by means of a cream has not been clearly established. The effectiveness of topical applications has been questioned due to vitamin C’s instability (it reacts with water and degrades). Some forms are said to have better stability in water systems. Synthetic analogues such as magnesium ascorbyl phosphate are among those considered more effective, as they tend to be more stable. When evaluating its ability to fight free-radical damage in light of its synergistic effect with vitamin e, vitamin C shines. As vitamin e reacts with a free radical, it, in turn, is damaged by the free radical it is fighting. Vitamin C comes in to repair the free-radical damage in vitamin e, allowing e to continue with its free-radical scavenging duties. Past research has indicated that high concentrations of topically applied vitamin C are photoprotective, and apparently the vitamin preparation used in these studies resisted soap and water, washing, or rubbing for three days. More current research has indicated that vitamin C does add protection against uVB damage when combined with uVB sunscreen chemicals. This would lead one to conclude that in combination with conventional sunscreen agents, vitamin C may allow for longer-lasting, broader sun protection. Again, the synergy between vitamins C and e can yield even better results, as apparently a combination of both provides very good protection from uVB damage. However, vitamin C appears to be significantly better than e at protecting against uVA damage. A further conclusion is that the combination of vitamins C, e, and sunscreen offers greater protection than the sum of the protection offered by any of the three ingredients acting alone. Vitamin C also acts as a collagen biosynthesis regulator. It is known to control intercellular colloidal substances such as collagen, and when formulated into the proper vehicles, can have a skin-lightening effect. Vitamin C is said to be able to help the body fortify against infectious conditions by strengthening the immune system. There is some evidence (although debated) that vitamin C can pass through the layers of the skin and promote healing in tissue damaged by burns or injury. It is found, therefore, in burn ointments and creams used for abrasions. Vitamin C is also popular in anti-aging products. Current studies indicate possible anti-inflammatory properties as well.

용도

Sodium, potassium, and calcium salts of ascorbic acids are called ascorbates and are used as food preservatives. To make ascorbic acid fat-soluble, it can be esterified. Esters of ascorbic acid and acids, such as palmitic acid to form ascorbyl palmitate and stearic acid to form ascorbic stearate, are used as antioxidants in food, pharmaceuticals, and cosmetics. Ascorbic acid is also essential in the metabolism of some amino acids. It helps protect cells from free radical damage, helps iron absorption, and is essential for many metabolic processes.

용도

The starting point for synthesis of vitamin C is the selective of oxidation of the sugar compound D-sorbit to L-sorbose using Acetobacter suboxidans bacteria. L-sorbose is then converted to L-ascorbic acid, better known as vitamin C.

Indications

Vitamin C (ascorbic acid) is essential for the maintenance of the ground substance that binds cells together and for the formation and maintenance of collagen.The exact biochemical role it plays in these functions is not known, but it may be related to its ability to act as an oxidation–reduction system.

생산 방법

Ascorbic acid is produced synthetically using the Reichstein process, which has been the standard method of production since the 1930s. The process starts with fermentation followed by chemical synthesis. The first step involves reduction of D-glucose at high temperature into D-sorbitol. D-sorbitol undergoes bacterial fermentation, converting it into L-sorbose. L-sorbose is then reacted with acetone in the presence of concentrated sulfuric acid to produce diacetone-L-sorbose, which is then oxidized with chlorine and sodium hydroxide to produce di-acetone-ketogulonic acid (DAKS). DAKS is then esterified with an acid catalyst and organics to give a gulonic acid methylester. The latter is heated and reacted with alcohol to produce crude ascorbic acid, which is then recrystallized to increase its purity. Since the development of the Reichstein process more than 70 years ago, it has undergone many modifications. In the 1960s, a method developed in China referred to as the two-stage fermentation process used a second fermentation stage of L-sorbose to produce a different intermediate than DAKS called KGA (2-keto-L-gulonic acid), which was then converted into ascorbic acid. The two stage process relies less on hazardous chemicals and requires less energy to convert glucose to ascorbic acid.

생산 방법

Ascorbic acid is prepared synthetically or extracted from various vegetable sources in which it occurs naturally, such as rose hips, blackcurrants, the juice of citrus fruits, and the ripe fruit of Capsicum annuum L. A common synthetic procedure involves the hydrogenation of D-glucose to D-sorbitol, followed by oxidation using Acetobacter suboxydans to form L-sorbose. A carboxyl group is then added at C1 by air oxidation of the diacetone derivative of Lsorbose and the resulting diacetone-2-keto-L-gulonic acid is converted to L-ascorbic acid by heating with hydrochloric acid.

정의

ChEBI: The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.

Manufacturing Process

D-Glucose was reduced to the D-sorbitol with a hydrogen over Ni Raney, then it was turned into the L-sorbose with the acetobacter suboxydans and the hydroxyl groups of L-sorbose were protected with acetone treatment yielded the diaceton-L-sorbose. Subsequent treatment with NaOCl/Raney Ni produced di-O-isopropylidene-2-oxo-L-gulonic acid. Partial hydrolysis with aqueous HCl gave deprotected 2-oxo-L-gulonic acid, which yielded ascorbinic acid by heating with HCl.

상표명

Ascorbin (Marion Merrell Dow).

Therapeutic Function

Vitamin

일반 설명

White to very pale yellow crystalline powder with a pleasant sharp acidic taste. Almost odorless.

일반 설명

Scurvy (from the French word scorbutus) has been recognized as a disease afflicting mankind for thousands of years. Citrus fruits such as oranges, lemons, and limes were later identified as equally effective treatments. Only within the last 100 years has a deficiency in vitamin C been definitively identified as the cause of scurvy. In 1932, Waugh and King isolated crystalline vitamin C from lemon juice and showed it to be the antiscorbutic factor present in each of these treatments.
The structure and chemical formula of vitamin C was identified in 1933 by Hirst et al.Because humans are one of the few animal species that cannot synthesize vitamin C, it has to be available as a dietary component. Dietary sources of ascorbic acid include fruits (especially citrus fruits), vegetables (especially peppers), and potatoes. Although the sources of some commercial products are rose hips and citrus fruits, most ascorbic acid is prepared synthetically.
Vitamin C is now commonly referred to as ascorbic acid because of its acidic character and its effectiveness in the treatment and prevention of scorbutus (scurvy). The acidic character is because of the two enolic hydroxyls; the C3 hydroxyl has a pKa value of 4.1, and the C2 hydroxyl has a pKa of 11.6. All biological activities reside in L-ascorbic acid; therefore, all references to vitamin C, ascorbic acid, ascorbate, and their derivatives refer to this form. The monobasic sodium salt is the usual salt form.

공기와 물의 반응

May be sensitive to prolonged exposure to air and light. Sensitive to moisture. Soluble in water. Aqueous solutions are oxidized by air in a reaction that is accelerated by alkalis, iron and copper. The rate depends on the pH and on oxygen concentration. Also subject to degradation under anaerobic conditions.

반응 프로필

L(+)-Ascorbic acid is a lactone. Reacts as a relatively strong reducing agent and decolorizes many dyes. Forms stable metal salts. Incompatible with oxidizers, dyes, alkalis, iron and copper. Also incompatible with ferric salts and salts of heavy metals, particularly copper, zinc and manganese .

화재위험

Flash point data for L(+)-Ascorbic acid are not available; however, L(+)-Ascorbic acid is probably combustible.

Pharmaceutical Applications

Ascorbic acid is used as an antioxidant in aqueous pharmaceutical formulations at a concentration of 0.01–0.1% w/v. Ascorbic acid has been used to adjust the pH of solutions for injection, and as an adjunct for oral liquids. It is also widely used in foods as an antioxidant. Ascorbic acid has also proven useful as a stabilizing agent in mixed micelles containing tetrazepam.

Pharmacology

Vitamin C is considered as a classical enzyme cofactor or antioxidant but also as a transition material in metal ion reaction. And all of these functions of vitamin C are related to the property of antioxidation.

Clinical Use

Vitamin C is indicated for the treatment and prevention of known or suspect deficiency. Although scurvy occurs infrequently, it is seen in the elderly, infants, alcoholics, and drug users.Ascorbate can also be used to enhance absorption of dietary nonheme iron or iron supplements. Ascorbic acid (but not the sodium salt) was historically used to acidify the urine as a result of excretion of unchanged ascorbic acid, although this use has fallen into disfavor. Ascorbate also increases iron chelation by deferoxamine, explaining its use in the treatment of iron toxicity.

Clinical Use

Vitamin C is found in fresh fruit and vegetables. It is very water soluble, is readily destroyed by heat, especially in an alkaline medium, and is rapidly oxidized in air. Fruit and vegetables that have been stored in air, cut or bruised, washed, or cooked may have lost much of their vitamin C content. The deficiency disease associated with a lack of ascorbic acid is called scurvy. Early symptoms include malaise and follicular hyperkeratosis. Capillary fragility results in hemorrhages, particularly of the gums. Abnormal bone and tooth development can occur in growing children.The body’s requirement for vitamin C increases during periods of stress, such as pregnancy and lactation.

부작용

Megavitamin intake of vitamin C may result in diarrhea due to intestinal irritation. Since ascorbic acid is partially metabolized and excreted as oxalate, renal oxalate stones may form in some patients.

Toxicology

L-Ascorbic acid, or vitamin C, is widely present in plants. The structures of ascorbic acid and dehydroascorbic acid are shown in Figure 10.5. Vitamin C is not only an important nutrient but is also used as an antioxidant in various foods. However, it is not soluble in fat and is unstable under basic conditions. Vitamin C reduces cadmium toxicity and excess doses prolong the retention time of an organic mercury compound in a biological system. Overdoses of vitamin C (106 g) induce perspiration, nervous tension, and lowered pulse rate. WHO recommends that daily intake be less than 0.15 mg/kg. Toxicity due to ascorbic acid has not been reported. Although repeated intravenous injections of 80 mg dehydroascorbic acid was reported to be diabetogenic in rats, oral consumption of 1.5 g/day of ascorbic acid for six weeks had no effect on glucose tolerance or glycosuria in 12 normal adult males and produced no change in blood glucose concentrations in 80 diabetics after five days. The same report noted that a 100-mg intravenous dose of dehydroascorbic acid given daily for prolonged periods produced no signs of diabetes. Ascorbic acid is readily oxidized to dehydroascorbic acid, which is reduced by glutathione in blood.

Safety Profile

Moderately toxic by ingestion and intravenous routes. Human systemic effects by intravenous route: blood, changes in tubules (including acute renal failure, acute tubular necrosis). An experimental teratogen. Other experimental reproductive effects. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.

Safety

Ascorbic acid is an essential part of the human diet, with 40 mg being the recommended daily dose in the UK and 60 mg in the USA. However, these figures are controversial, with some advocating doses of 150 or 250mg daily. Megadoses of 10 g daily have also been suggested to prevent illness although such large doses are now generally considered to be potentially harmful.
The body can absorb about 500 mg of ascorbic acid daily with any excess immediately excreted by the kidneys. Large doses may cause diarrhea or other gastrointestinal disturbances. Damage to the teeth has also been reported. However, no adverse effects have been reported at the levels employed as an antioxidant in foods, beverages, and pharmaceuticals. The WHO has set an acceptable daily intake of ascorbic acid, potassium ascorbate, and sodium ascorbate, as antioxidants in food, at up to 15 mg/kg bodyweight in addition to that naturally present in food.
LD50 (mouse, IV): 0.52 g/kg
LD50 (mouse, oral): 3.37 g/kg
LD50 (rat, oral): 11.9 g/kg

저장

In powder form, ascorbic acid is relatively stable in air. In the absence of oxygen and other oxidizing agents it is also heat stable. Ascorbic acid is unstable in solution, especially alkaline solution, readily undergoing oxidation on exposure to the air.The oxidation process is accelerated by light and heat and is catalyzed by traces of copper and iron. Ascorbic acid solutions exhibit maximum stability at about pH 5.4. Solutions may be sterilized by filtration.
The bulk material should be stored in a well-closed nonmetallic container, protected from light, in a cool, dry place.

Purification Methods

Crystallise it from MeOH/Et2O/pet ether [Herbert et al. J Chem Soc 1270 1933]. [Beilstein 18/5 V 26.]

Toxicity evaluation

Metabolism of ascorbic acid can lead to deposition of oxalate crystals in kidney tissue. Reduction of carcinogenic Cr(VI) by ascorbic acid generates ascorbate–Cr(III)–DNA cross-links that have been linked to mutagenicity and the formation of DNA lesions. Uranyl acetate–ascorbate has also been shown to nick plasmid DNA.

비 호환성

Incompatible with alkalis, heavy metal ions, especially copper and iron, oxidizing materials, methenamine, phenylephrine hydrochloride, pyrilamine maleate, salicylamide, sodium nitrite, sodium salicylate, theobromine salicylate, and picotamide. Additionally, ascorbic acid has been found to interfere with certain colorimetric assays by reducing the intensity of the color produced.

Regulatory Status

GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (inhalations, injections, oral capsules, suspensions, tablets, topical preparations, and suppositories). Included in medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

비타민 C 준비 용품 및 원자재

원자재

준비 용품


비타민 C 공급 업체

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