프리스티메린
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프리스티메린 속성
- 녹는점
- 219.5°C
- 끓는 점
- 488.1°C (rough estimate)
- 밀도
- 1.0271 (rough estimate)
- 굴절률
- 1.4800 (estimate)
- 저장 조건
- -20°C
- 용해도
- DMSO: ≥5mg/mL
- 물리적 상태
- 빨간색 고체
- 산도 계수 (pKa)
- 8.60±0.70(Predicted)
- 색상
- 오렌지 레드
- 색상
- 오렌지색
안전
독성 | LD50 oral in mouse: 8gm/kg |
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프리스티메린 C화학적 특성, 용도, 생산
개요
Monoacylglycerol lipase (MAGL) hydrolyzes the endogenous cannabinoid 2-용도
Pristimerin is a triterpenoid that inhibits tumor angiogenesis by targeting VEGFR2 activation and is known to exhibit anti-inflammatory properties.일반 설명
A cell-permeable plant dienone-phenolic triterpenoid, naturally isolated from tripterygium wilfordii, whose inhibitory activities against proteasome chymotrypsin subunit (IC50 = 2.2 and 3.0 μM against purified rabbit 20S and human 26S proteasome, respectively) and cellular NF-κB pathway/IKK activation most likely account for its reported anticancer efficacy both in vitro (IC50 ≤610 nM in A549, K562, KBM5, MCF-7, MDA-MB-231, HepG2, and primary human leukemia cell cultures) and in mice in vivo (1 to 2.5 mg/kg/day, s.c.), including imatinib/STI571-resistant cancer cells harboring Bcr-Abl T315I mutation. Also reported to inhibit the activity of monoacylglycerol lipase (MGL), the enzyme that hydrolyzes and deactivates the cannabionoid receptor ligand 2-Arachidonoyl-sn-glycerol (2-AG), in a reversible manner with high potency (IC50 = 93 nM).생물학적 활성
Potent and reversible inhibitor of monoacylglycerol lipase (MGL) (IC 50 = 93 nM). Also suppresses NF- κ B activation via inhibition of proteasome chymotrypsin-like activity and IKK α / β . Displays antitumor, anti-inflammatory and antimicrobial activities.프리스티메린 준비 용품 및 원자재
원자재
준비 용품
프리스티메린 공급 업체
글로벌( 166)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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Shaanxi Dideu Medichem Co. Ltd | +86-29-81148696 +86-15536356810 |
1022@dideu.com | China | 3878 | 58 |
Hebei Yanxi Chemical Co., Ltd. | +8617531190177 |
peter@yan-xi.com | China | 5873 | 58 |
Shanghai Zheyan Biotech Co., Ltd. | 18017610038 |
zheyansh@163.com | CHINA | 3620 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29888 | 58 |
Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 |
scglp@glp-china.com | CHINA | 1824 | 58 |
Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 |
sales@biopurify.com | China | 3772 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 |
sales@pioneerbiotech.com | China | 3000 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39916 | 58 |
Shanghai Standard Technology Co., Ltd. | 18502101150 |
ft-sales@nature-standard.com | CHINA | 1923 | 58 |
프리스티메린 관련 검색:
악티게닌 오리도닌 1-메틸-4-(1-메틸에틸)-1,3-사이클로헥사디엔 프리스티메린
Cisplatin
Carboplatin
Arctiin
1-O-OCTADECYL-2-O-METHYL-SN-GLYCERO-3-PHOSPHOCHOLINE
Pyrrolcarbonyltaloside
gamma-Linolenic acid
Baccatine III
Oxaliplatin
Isorhamnetin
FRIEDELAN-3BETA-OL
lithospermic acid
Taxifolin
Celastrol
2,2,4,4,5,5,7,7-OCTAMETHYLOCTANE