sorivudine
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sorivudine 속성
- 녹는점
- 182° (Sakata, 1980); mp 195-200° (dec) (Machida, Sakata, 1983)
- 알파
- D25 +0.5° (1N NaOH)
- 밀도
- 1.979±0.06 g/cm3(Predicted)
- 저장 조건
- Store at -20°C
- 용해도
- DMSO: 250 mg/mL (716.07 mM)
- 산도 계수 (pKa)
- 8.37±0.10(Predicted)
안전
| 독성 | LD50 in mice (mg/kg): ~3300 i.p.; >5000 s.c.; >10000 orally (Machida, Sakata, 1984) |
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sorivudine C화학적 특성, 용도, 생산
개요
Sorivudine is an orally-active antiviral nucleoside analog. It has potent and selective activity against herpes simplex virus type-1 (HSV-1) and varicella-zoster virus (VZV). In a cutaneous model infection of mice with HSV-1, oral administration of sorivudine at dose of 20 mg/kg resulted in a significant increase in the survival rate. Five percent sorivudine cream is also useful in the topical treatment of cutaneous HSV-1 infection, including immunocompromised patients. It has been suggested that its antiviral activity may be mediated by inhibition of DNA synthesis in virus infected cells.Since the metabolite of sorivudine inhibits the enzyme for pyrimidine catabolism, caution should be taken not to use sorivudine in combination with fluorouracil drugs in order to avoid hematological disorders.
용도
Sorivudine is an antimetabolite drug and can be used to synthesize antiviral compounds as well as compounds that can treat diseases of viral etiol.sorivudine 준비 용품 및 원자재
원자재
준비 용품
sorivudine 공급 업체
글로벌( 22)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Changzhou PBpharmaceutical R&D Co.,Ltd | 0519-83990708 |
info@pbpharm.com | CHINA | 498 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 |
Mandy@hangyubiotech.com | China | 11013 | 58 |
| LGM Pharma | 1-(800)-881-8210 |
inquiries@lgmpharma.com | United States | 2127 | 70 |
| Changzhou PBpharmaceutical R&D Co.,Ltd | 0519-83990708 |
lxy2046@yeah.net | China | 480 | 55 |
| Shanghai Kaiwei Chemical Technology Co., Ltd. | 021-58461859 15821823057 |
service@aiviche.com | China | 49323 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 |
marketing@energy-chemical.com | China | 44941 | 58 |
| InvivoChem | 13549236410 |
sales@invivochem.cn | China | 6712 | 58 |
| Shanghai Haohong Pharmaceutical Co., Ltd. | 400-8210725 4008210725 |
malulu@leyan.com | China | 40036 | 58 |
| Changzhou Bojia Biomedical Technology Co., Ltd. | 2122619822 |
czbjpharma@126.com | China | 18488 | 58 |