sorivudine
- CAS No.
- 77181-69-2
- Chemical Name:
- sorivudine
- Synonyms
- YN-72;BvAraU;D01734;BV-araU;Bravavir;Brovavir;Sorivudin;sorivudine;Bravavir (tn);Sorivudine (jan/usan/inn)
- CBNumber:
- CB51074625
- Molecular Formula:
- C11H13BrN2O6
- Molecular Weight:
- 349.13
- MDL Number:
- MOL File:
- 77181-69-2.mol
| Melting point | 182° (Sakata, 1980); mp 195-200° (dec) (Machida, Sakata, 1983) |
|---|---|
| alpha | D25 +0.5° (1N NaOH) |
| Density | 1.979±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO: 250 mg/mL (716.07 mM) |
| pka | 8.37±0.10(Predicted) |
| NCI Dictionary of Cancer Terms | sorivudine |
| FDA UNII | C7VOZ162LV |
SAFETY
Risk and Safety Statements
| Toxicity | LD50 in mice (mg/kg): ~3300 i.p.; >5000 s.c.; >10000 orally (Machida, Sakata, 1984) |
|---|
sorivudine price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | S677200 | Sorivudine | 77181-69-2 | 100mg | $605 | 2021-12-16 | Buy |
| ChemScene | CS-0080932 | Sorivudine 95.03% | 77181-69-2 | 50mg | $700 | 2021-12-16 | Buy |
| ChemScene | CS-0080932 | Sorivudine 95.03% | 77181-69-2 | 5mg | $145 | 2021-12-16 | Buy |
| ChemScene | CS-0080932 | Sorivudine 95.03% | 77181-69-2 | 10mg | $230 | 2021-12-16 | Buy |
| ChemScene | CS-0080932 | Sorivudine 95.03% | 77181-69-2 | 25mg | $420 | 2021-12-16 | Buy |
sorivudine Chemical Properties,Uses,Production
Description
Sorivudine is an orally-active antiviral nucleoside analog. It has potent and selective
activity against herpes simplex virus type-1 (HSV-1) and varicella-zoster virus (VZV). In a
cutaneous model infection of mice with HSV-1, oral administration of sorivudine at dose of
20 mg/kg resulted in a significant increase in the survival rate. Five percent sorivudine cream
is also useful in the topical treatment of cutaneous HSV-1 infection, including
immunocompromised patients. It has been suggested that its antiviral activity may be
mediated by inhibition of DNA synthesis in virus infected cells.
Since the metabolite of sorivudine inhibits the enzyme for pyrimidine catabolism,
caution should be taken not to use sorivudine in combination with fluorouracil drugs in order to
avoid hematological disorders.
Originator
Yamasa Shoyu (Japan)
Uses
Sorivudine is an antimetabolite drug and can be used to synthesize antiviral compounds as well as compounds that can treat diseases of viral etiol.
Uses
Antiviral.
Definition
ChEBI: Sorivudine is an organic molecular entity.
brand name
Bravavir (Bristol-Myers Squibb);Usevir.
sorivudine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Changzhou PBpharmaceutical R&D Co.,Ltd | 0519-83990708 | info@pbpharm.com | CHINA | 498 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 11013 | 58 |
| LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2127 | 70 |
| Changzhou PBpharmaceutical R&D Co.,Ltd | 0519-83990708 | lxy2046@yeah.net | China | 480 | 55 |
| Shanghai Kaiwei Chemical Technology Co., Ltd. | 021-58461859 15821823057 | service@aiviche.com | China | 49323 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44941 | 58 |
| InvivoChem | 13549236410 | sales@invivochem.cn | China | 6712 | 58 |
| Shanghai Haohong Pharmaceutical Co., Ltd. | 400-8210725 4008210725 | malulu@leyan.com | China | 40036 | 58 |
| Changzhou Bojia Biomedical Technology Co., Ltd. | 2122619822 | czbjpharma@126.com | China | 18488 | 58 |