CARUMONAM

CARUMONAM 구조식 이미지
카스 번호:
87638-04-8
상품명:
CARUMONAM
동의어(영문):
AMA 1080;CARUMONAM;Ro 17-2301;CarlliIIonaln;CARUMONAM USP/EP/BP;Ro-17-2301:A-masulin;Antibiotic Ro 17-2301;(2S)-2α-(Carbamoyloxymethyl)-3α-[[(Z)-(2-amino-4-thiazolyl)[(carboxymethoxy)imino]acetyl]amino]-4-oxoazetidine-1-sulfonic acid;[[[(Z)-2-[[(2S)-2α-[[(Aminocarbonyl)oxy]methyl]-4-oxo-1-sulfoazetidin-3α-yl]amino]-1-(2-aminothiazol-4-yl)-2-oxoethylidene]amino]oxy]acetic acid;[[[(Z)-2-[[(2S,3S)-2-[[(Aminocarbonyl)oxy]methyl]-4-oxo-1-sulfoazetidin-3-yl]amino]-1-(2-amino-4-thiazolyl)-2-oxoethylidene]amino]oxy]acetic acid
CBNumber:
CB5165269
분자식:
C12H14N6O10S2
포뮬러 무게:
466.4
MOL 파일:
87638-04-8.mol

CARUMONAM 속성

알파
D26 -45° (c = 1 in DMSO)
밀도
2.13±0.1 g/cm3(Predicted)
산도 계수 (pKa)
-0.43±0.60(Predicted)

안전

CARUMONAM C화학적 특성, 용도, 생산

개요

Canunonam is an injectable antibiotic, the second monobactam ever developed (the first being Squibb’s aztreonam). It is highly active against Gram negative bacteria, particularly pseudomom, and is reportedly effective in the treatment of pneumonia, cystitis, peritonitis and secondary infections.

정의

ChEBI: An N-sulfonated monobactam antibiotic.

Antimicrobial activity

A synthetic monobactam with activity against common pathogenic organisms similar to that of aztreonam. It is resistant to hydrolysis by the common plasmid and chromosomal β-lactamases, but it can be hydrolyzed by ESBLs.
It is administered intravenously, achieving a concentration of c. 78 mg/L after a 20-min infusion of 1 g. The plasma halflife is 1.7 h and the plasma protein binding 18–28%. Carumonam is almost entirely eliminated in the glomerular filtrate, probenecid having no effect on excretion; 96% of labeled compound is found in the urine, with 3% in the feces. Between 68% and 91% of the dose appears in the urine within 24 h.
Side effects and clinical use are similar to those of aztreonam.

CARUMONAM 준비 용품 및 원자재

원자재

준비 용품


CARUMONAM 공급 업체

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