4-TRIMETHYLSILYL-3-BUTYN-2-OL
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4-TRIMETHYLSILYL-3-BUTYN-2-OL 속성
- 끓는 점
- 76 °C
- 밀도
- 0.847 g/mL at 25 °C
- 굴절률
- n
20/D 1.446
- 인화점
- 143 °F
- 저장 조건
- 2-8°C
- 용해도
- highly soluble in all standard organic solvents (hexanes, toluene, CH2Cl2, EtOAc, alcohols, ethers). Partially soluble in water.
- 산도 계수 (pKa)
- 13.78±0.20(Predicted)
- 물리적 상태
- 투명한 액체
- 색상
- Colorless to Light orange to Yellow
- Specific Gravity
- 0.846
- Hydrolytic Sensitivity
- 4: no reaction with water under neutral conditions
- BRN
- 1923632
- CAS 데이터베이스
- 6999-19-5(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xi | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 36/37/38 | ||
| 안전지침서 | 26 | ||
| 유엔번호(UN No.) | 1993 | ||
| WGK 독일 | 3 | ||
| TSCA | No | ||
| 위험 등급 | 3 | ||
| 포장분류 | III | ||
| HS 번호 | 29319090 |
4-TRIMETHYLSILYL-3-BUTYN-2-OL C화학적 특성, 용도, 생산
화학적 성질
Colorless liquid물리적 성질
bp 83–85°C (13 mmHg).용도
More recently, Mulzer has reported use of the corresponding allenylsilane derived from 4-TMS-3-butyn-2-ol for use in the synthesis of the C13–C18 fragment of branimycin (eq 2).
제조 방법
racemic 4-trimethylsilyl-3-butyn-2-ol can be prepared by deprotonation with strong bases (BuLi, LDA, Grignards reagents) of trimethylsilylacetylene followed by addition to acetaldehyde.Deprotonation of 3-butyn-2- ol followed by quenching with excess trimethylsilyl chloride followed by concomitant hydrolysis of the trimethylsilyl ether is generally the most straightforward route.Enzymatic reduction of 4-TMS-3-butyn-2-one has also been used to prepare the reagent using alcohol dehydrogenase.Preparation of nonracemic 4-TMS-3-butyn-2-ol has been accomplished by asymmetric addition of dimethylzinc to acetaldehyde promoted by TADDOL or addition of a trimethylsilylvinylsulfoxide to acetaldehyde followed by thermal elimination of the sulfoxide.Asymmetric reduction of 4- TMS-3-butyn-2-one using stoichiometric reducing reagents, catalytic transfer hydrodrogenation,and enzymatic reduction with isolated protein or whole cells afford the 4-TMS-3-butyn- 2-ol with varying degrees of enantioenrichment.Enzymatic resolution by esterification of the racemic alcohol is the method of choice for the large-scale preparation.
4-TRIMETHYLSILYL-3-BUTYN-2-OL 준비 용품 및 원자재
원자재
준비 용품
4-TRIMETHYLSILYL-3-BUTYN-2-OL 공급 업체
글로벌( 115)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 18628 | 58 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9287 | 55 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Hubei Co-Formula Material Tech Co., Ltd. | +86-27-84459282 |
sales@cfmats.com | CHINA | 882 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 |
laboratory@coreychem.com | China | 30250 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 |
sales@tnjchem.com | China | 34571 | 58 |
| Alfa Chemistry | |
info@alfa-chemistry.com | United States | 2344 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 |
info@dycnchem.com | China | 52861 | 58 |
| CD Chemical Group Limited | +8615986615575 |
info@codchem.com | China | 20356 | 58 |
| Bio Connect Life Sciences | |
info@bio-connect.nl | United States | 261 | 58 |
4-TRIMETHYLSILYL-3-BUTYN-2-OL 관련 검색:
2-METHYL-4-TRIMETHYLSILYL-3-BUTYN-2-OL (+/-),(+/-) 2-METHYL-4-TRIMETHYLSILYL-3-BUTYN-2-OL,2-METHYL-4-TRIMETHYLSILYL-3-BUTYN-2-OL
4-TRIMETHYLSILYL-3-BUTYN-2-OL
3-Butyn-2-ol
3-BUTYN-2-OL
1-PHENYL-3-(TRIMETHYLSILYL)-2-PROPYN-1-&
5-TRIMETHYLSILYL-1-PENTEN-4-YN-3-OL
1-CYCLOHEXYL-3-(TERT-BUTYLDIMETHYLSILYL)-2-PROPYN-1-OL
2-HYDROXY-4-(TRIMETHYLSILYL)-3-BUTYNOIC ACID ETHYL ESTER
3-METHYL-1-TRIMETHYLSILYL-1-PENTYN-3-OL (+/-)
4-TRIMETHYLSILYL-3-BUTYN-1-OL
5-O-(P-CHLOROBENZOYL)-3-C-(2-TRIMETHYLSILYLETHYNYL)-D-RIBOFURANOSE
1-(Trimethylsilyl)-1-butyn-4-ol
1-ISO-PROPYL-3-(1,1,1-TRIMETHYLSILYL)-2-PROPYN-1-OL
1-CYCLOPROPYL-3-TRIMETHYLSILANYL-PROP-2-YN-1-OL
3-(1-CYCLOPROPYL-3-TRIMETHYLSILANYL-PROP-2-YNYLOXY)-4,5-DIMETHOXY-BENZALDEHYDE
1-PHENYL-3-(TERT-BUTYLDIMETHYLSILYL)-2-PROPYN-1-OL
1,5-DI(TERT-BUTYLDIMETHYLSILYL)-1,4-PENTADIYN-3-OL
1-(TERT-BUTYLDIMETHYLSILYL)-5-(TRIISOPROPYLSILYL)-1,4-PENTADIYN-3-OL