리튬 아마이드
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리튬 아마이드 속성
- 녹는점
- 373 °C
- 끓는 점
- 430 °C
- 밀도
- 1.178 g/mL at 25 °C(lit.)
- 굴절률
- 1.178g/mL
- 저장 조건
- water-free area
- 용해도
- 에탄올과 액체 암모니아에 약간 용해됩니다. 무수 에테르, 벤젠 및 톨루엔에 용해되지 않습니다.
- 물리적 상태
- 가루
- Specific Gravity
- 1.178
- 색상
- 회백색
- 수용성
- 물과 반응
- 감도
- Air & Moisture Sensitive
- Merck
- 14,5522
- InChIKey
- AFRJJFRNGGLMDW-UHFFFAOYSA-N
- LogP
- 0.23 at 25℃
- CAS 데이터베이스
- 7782-89-0(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | F,C | ||
---|---|---|---|
위험 카페고리 넘버 | 14/15-29-34-20/21/22-15-14-11 | ||
안전지침서 | 26-36/37/39-43-45-7/8-43B-16-3/7/9 | ||
유엔번호(UN No.) | UN 1390 4.3/PG 2 | ||
WGK 독일 | 2 | ||
RTECS 번호 | OJ5590000 | ||
TSCA | Yes | ||
위험 등급 | 4.3 | ||
포장분류 | II | ||
HS 번호 | 28530090 | ||
유해 물질 데이터 | 7782-89-0(Hazardous Substances Data) | ||
기존화학 물질 | KE-22545 |
리튬 아마이드 C화학적 특성, 용도, 생산
화학적 성질
white to grey fine powder물리적 성질
Colorless needles; tetragonal structure; density 1.178 g/cm3 at 17.5°C; melts around 375°C; starts to decompose at 320°C; decomposes at 400°C; soluble in cold water; decomposes in hot water; slightly soluble in ethanol and liquid ammonia; insoluble in benzene and ether.용도
Lithium amide is used in the preparation of active pharmaceutical ingredients and antioxidants. It acts as a catalyst for polymers, as nucleophiles and as strong bases. It serves as a reagent in the synthesis of antiinflamatory and preoresolving protectin D1, chemotype dipeptidyl peptidase IV inhibitors and sterically congested triarylamines. It finds application in dyes displaying large stokes shifts. In addition to this, it is used as a reagent for cross-coupling of aryl chlorides and amine.제조 방법
Lithium amide, LiNH2 , may be considered the ammonia analogue of lithium hydroxide in the water system. Lithium amide may be prepared from lithium hydride or lithium metal and ammonia. Industrial preparations use lithium hydride as a starting material.The reaction of lithium metal in a stream of ammonia gas at about 400°C may be used successfully as a preparative method. Lithium may also be reacted with liquid ammonia in the presence of an iron compound as a catalyst.
Since amide ion is the strongest base which can exist in ammonia, lithium amide is a very strong base. The compound has a low solubility in liquid ammonia. Lithium amide is hydrolyzed by water to yield lithium hydroxide and ammonia. It is readily oxidized. For example, the substance may be oxidized with dinitrogen oxide to yield lithium azide. Amides of the alkali metals in general must be guarded against air oxidation to prevent the formation of potentially explosive substances.
일반 설명
White crystalline powder with an odor of ammonia. Denser than water.반응 프로필
Powdered Lithium amide is highly reactive. A strong base. Reacts to release toxic ammonia gas with water. Forms explosive peroxide on storage.건강위험
Highly toxic: contact with water produces toxic gas, may be fatal if inhaled. Inhalation or contact with vapors, substance or decomposition products may cause severe injury or death. May produce corrosive solutions on contact with water. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control may cause pollution.화재위험
Produce flammable and toxic gases on contact with water. May ignite on contact with water or moist air. Some react vigorously or explosively on contact with water. May be ignited by heat, sparks or flames. May re-ignite after fire is extinguished. Some are transported in highly flammable liquids. Containers may explode when heated. Runoff may create fire or explosion hazard.Safety Profile
A powerful irritant to skin, eyes, and mucous membranes. Flammable when exposed to heat or flame. Ammonia is liberated and lithmm hydroxide is formed when this compound is exposed to moisture. Reacts violently with water or steam to produce toxic and flammable vapors. Vigorous reaction with oxilzing materials. Exothermic reaction with acid or acid fumes. When heated to decomposition it emits very toxic fumes of LiO, NH3, and NO,. Used in synthesis of drugs, vitamins, steroids, and other organics. See also LITHIUM COMPOUNDS, AMIDES, AMMONIA, and LITHIUM HYDROXIDE.Purification Methods
Purify it by heating at 400o while NH3 is passed over it in the upper of two crucibles (the upper crucible is perforated). The LiNH2 will drip into the lower crucible through the holes in the upper crucible. The product is cooled in a stream of NH3. Protect it from air and moisture, store it under N2 in a clear glass bottle sealed with paraffin. Store it in small quantities so that all the material is used once the bottle is opened. If the colour of the amide is yellow, it should be destroyed as it is likely to have oxidised and to EXPLODE. On heating above 450o it is decomposed to Li2NH, which is stable up to 750-800o. [Schenk in Handbook of Preparative Inorganic Chemistry (Ed. Brauer) Academic Press Vol I p 463 1963, Greenlee & Henne Inorg Synth II 135 1953.]리튬 아마이드 준비 용품 및 원자재
원자재
준비 용품
리튬 아마이드 공급 업체
글로벌( 164)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21667 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29888 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 |
linda@hubeijusheng.com | CHINA | 22968 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39916 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49392 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
factory@coreychem.com | China | 29823 | 58 |
Antai Fine Chemical Technology Co.,Limited | 18503026267 |
info@antaichem.com | CHINA | 9641 | 58 |
SIMAGCHEM CORP | +86-13806087780 |
sale@simagchem.com | China | 17367 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 |
sales@tnjchem.com | China | 34571 | 58 |
AFINE CHEMICALS LIMITED | +86-0571-85134551 |
info@afinechem.com | China | 15394 | 58 |