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tert-butyl azidoformate

tert-butyl azidoformate 구조식 이미지

카스 번호:: 1070-19-5

상품명:: tert-butyl azidoformate

동의어(영문):: t-Butyl Azidoformate;Azacitidine Impurity 52;tert-butyl azidoformate;ert-butylN-diazocarbamate;Azido tert-butoxymethanone;tert-butyl N-diazocarbamate;(tert-Butoxycarbonyl) azide;N-(tert-butyloxycarbonyl) azide;Azidoformic acid tert-butyl ester;Azidocarbonic acid tert-butyl ester

CBNumber:: CB5892220

분자식:: C5H9N3O2

포뮬러 무게:: 143.14386

MOL 파일:: 1070-19-5.mol

속성

안전

용도

공급 업체 8

tert-butyl azidoformate 속성

끓는 점: 261.22°C (rough estimate)

밀도: 1.3172 (rough estimate)

굴절률: 1.6190 (estimate)

EPA: Carbonazidic acid, 1,1-dimethylethyl ester (1070-19-5)

안전

tert-butyl azidoformate C화학적 특성, 용도, 생산

용도

t-Butyl azidoformate is a convenient reagent for the acylation of amines, hydrazines, and similar compounds.

제조 방법

tert-Butyl chloroformate was prepared in solution as follows. Dry phosgene was introduced into a solution of 18 g (0.24 mol) of tert-butyl alcohol in 500 ml of anhydrous ether until about 52 g (0.5 mol) had been absorbed and the mixture was cooled in a Dry Ice-acetone bath. Then a solution of 20 g (0.28 mol) of pyridine in 200 ml of anhydrous ether was added dropwise with vigorous stirring. The reaction mixture was stored overnight in a Dry Ice box. The precipitated pyridine hydrochloride was filtered and the volume of the filtrate was reduced to -70 ml at reduced pressure with cooling in an icewater bath.This cold solution of tert-butyl chloroformate was added over 30 min to a vigorously stirred solution of 31.6 g (0.2 mol) of tetramethylguanidinium azide in 200 ml of chloroform; the temperature was kept at 0°C throughout the addition. The bath was removed and the reaction mixture stirred for an additional hour and then poured into 500 nil of ice water containing -2 ml of acetic acid. Extraction with two 60-ml portions of ether followed by careful evaporation of the dried (magnesium sulfate) organic phase gave tert-butyl azidoformate as a pale amber liquid in quantitative yield.
The Direct Preparation of tert-Butyl Azidoformate

Synthesis Reference(s)

Journal of the American Chemical Society, 81, p. 955, 1959 DOI: 10.1021/ja01513a049
Tetrahedron Letters, 25, p. 3701, 1984 DOI: 10.1016/0040-4039(84)80109-4

Safety Profile

An unstable shockand heat-sensitive explosive. It may explode above 100°C and iptes at 143°C. When heated to decomposition it emits toxic fumes of NOx. See also AZIDES.

tert-butyl azidoformate 준비 용품 및 원자재

원자재

TERT-BUTYL N-ALLYLCARBAMATE

준비 용품

Boc-Aib-OH N-BOC-1,6-diaminohexane BOC-L-Methionine BOC-L-4-Nitrophe DI-TERT-BUTYL HYDRAZODICARBOXYLATE Boc-N-Me-Val-OH Boc-L-Threonine 1,9-BIS-BOC-1,5,9-TRIAZANONANE 1-BOC-1,10-DIAMINODECANE N-Boc-N-methyl glycine methyl ester BOC-1,4-DIAMINOBUTANE HYDROCHLORIDE TERT-BUTYL N-(TERT-BUTOXYCARBONYLOXY)CARBAMATE N-T-BOC-PYRROLE

tert-butyl azidoformate 공급 업체

글로벌( 8)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131981	58
Mashilabs (Shanghai) Co.,Ltd.	021-00000000 19916721580	info@mashilabs.com	China	4115	58
ATK CHEMICAL COMPANY LIMITED	3429815786 13301662590	sales@atkchemical.com	China	10007	55
Shaanxi Dideu Medichem Co. Ltd	029-81124267 15229202216	1073@dideu.com	China	10011	58

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tert-butyl azidoformate