라모플라닌
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라모플라닌 속성
- 녹는점
- 210-230°
- 알파
- D20 +78.3° (c = 1.04 in H2O)
- 저장 조건
- -20°C
- 용해도
- H2O: 용해성10mg/mL
- 물리적 상태
- 가루
- 색상
- 흰색에서 황백색까지
- InChIKey
- FSBZBQUUCNYWOK-KFTDLNJOSA-N
라모플라닌 C화학적 특성, 용도, 생산
개요
Ramoplanin (A 16686, A16686A, MDL 62198) is a novel oral nonabsorbable 17-amino-acid cyclic lipoglycodepsipeptide antibiotic from Biosearch Italy. Ramoplanin is an antibiotic complex, first identified in 1984, that was isolated from the fermentation broth of Actinoplanes sp. ATCC 33076. It is a mixture of three closely related compounds, ramoplanin A1–A3, which differ only in the acyl group attached to the Asn-1 N-terminus; ramoplanin A2 is the most abundant.용도
Ramoplanin is a potent cyclic lipoglycodepsipeptide antibiotic that exhibits wide spectrum of antibiotic properties against gram-positive and gram-negative bacteria.Antimicrobial activity
Ramoplanin displays activity against aerobic and anaerobic Grampositive bacteria by preventing cell wall peptidoglycan formation through binding to a key intermediate moiety, lipid II, and thereby disrupting bacterial cell wall synthesis. The primary use of ramoplanin is in the treatment of Clostridium difficile infections.Mechanism of action
The mechanism of action of ramoplanin involves sequestration of peptidoglycan biosynthesis lipid intermediates, thus physically occluding these substrates from proper utilization by the latestage peptidoglycan biosynthesis enzymes MurG and the transglycosylases (TGases). Ramoplanin is structurally related to two cell wall-active lipodepsipeptide antibiotics, janiemycin and enduracidin, and is functionally related to members of the lantibiotic class of antimicrobial peptides (mersacidin, actagardine, nisin, and epidermin) and glycopeptide antibiotics. As a consequence of its unique mechanism of action, cross-resistance with existing glycopeptides and beta-lactam antibiotics has not been observed.Pharmacokinetics
Ramoplanin is not absorbed from the intestinal tract. When ramoplanin (200 and 400 mg) was administered orally to two groups of healthy volunteers over a period of 10 days, no ramoplanin could be detected in plasma and urine. With the 200-mg dose, concentrations in stools varied between 467 and 1043 mg/g, and with the 400-mg dose, concentrations were between 765 and 2032 mg/g. Results from an in vitro gut model and hamster model revealed that ramoplanin may be more effective than vancomycin at killing spores and preventing spore recrudescence.Toxicology
When administered orally in a double-blind randomized placebocontrolled study, no adverse reactions were observed in patients receiving two daily doses of ramoplanin (100 or 400 mg) in comparison with the placebo. Single and repeated topical application in ten healthy human volunteers revealed very low irritation rates and no sensitization after 21 days.라모플라닌 준비 용품 및 원자재
원자재
준비 용품
라모플라닌 공급 업체
글로벌( 91)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 |
contact@fuxinpharm.com | China | 10297 | 58 |
AFINE CHEMICALS LIMITED | +86-0571-85134551 |
info@afinechem.com | China | 15394 | 58 |
BOC Sciences | 16314854226; +16314854226 |
inquiry@bocsci.com | United States | 19743 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 |
sales@sarms4muscle.com | China | 10522 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 |
sales@tnjchem.com | China | 25363 | 58 |
Chengdu Youngshe Chemical Co., Ltd. | +8618108235634 |
Cecilia@youngshechem.com | China | 2345 | 58 |
Hebei Miaoyin Technology Co.,Ltd | +86-17367732028 +86-17367732028 |
kathy@hbyinsheng.com | China | 3581 | 58 |
LEAPCHEM CO., LTD. | +86-852-30606658 |
market18@leapchem.com | China | 43348 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 |
sales@aladdinsci.com | United States | 57511 | 58 |
Hangzhou J&H Chemical Co., Ltd. | 0571-+86-571-87396432 |
sales@jhechem.com | China | 11369 | 59 |
라모플라닌 관련 검색:
실버 아세틸아세토네이트 아세틸아세톤산 구리 코발트(II) 아세틸아세토네이트 하이드레이트 알루미늄 아세틸아세토네이트 디스프로슘 트리(2,2,6,6-테트라메틸-3,5-헵탄디오네이트) 아세틸아세토산 제2철
METHYL ISOCYANOACETATE
PHENYLSELENOL
TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III)
Ethyl isocyanoacetate
Benzyl isocyanide
DICHLORO(ETHYLENEDIAMINE)PLATINUM(II)
1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE
Tosylmethyl isocyanide
TERT-BUTYL ISOCYANIDE
SALCOMINE
N-BUTYLISOCYANIDE
Tris(2,4-pentanedionato)chroMiuM(III)