GSK 2334470

GSK 2334470 구조식 이미지
카스 번호:
1227911-45-6
상품명:
GSK 2334470
동의어(영문):
CS-1873;GSK 2334470;GSK 2334470 USP/EP/BP;GSK2334470 GSK-2334470;PDK1 inhibitor GS2334470;GSK2334470;GSK 2334470;GSK-2334470;1S,4R)-3-(6-(3-AMINO-1H-INDAZOL-6-YL)-2-(METHYLAMINO)PYRIMIDIN-4-YL)-N-CYCLOHEXYL-4-METHYLCYCLOHEXAN;1S,4R)-3-(6-(3-aMino-1H-indazol-6-yl)-2-(MethylaMino)pyriMidin-4-yl)-N-cyclohexyl-4-MethylcyclohexanecarboxaMide;(3S,6R)-1-[6-(3-Amino-1H-indazol-6-yl)-2-(methylamino)-4-pyrimidinyl]-N-cyclohexyl-6-methyl-3-piperidinecarboxamide;((3S,6R)-1-(6-(3-amino-1H-indazol-6-yl)-2-(methylamino)pyrimidin-4-yl)-6-methylpiperidin-3-yl)(piperidin-1-yl)methanone
CBNumber:
CB62596521
분자식:
C25H34N8O
포뮬러 무게:
462.59
MOL 파일:
1227911-45-6.mol
MSDS 파일:
SDS

GSK 2334470 속성

밀도
1.30±0.1 g/cm3(Predicted)
저장 조건
2-8°C
용해도
DMSO: ≥10mg/mL
산도 계수 (pKa)
12.84±0.40(Predicted)
물리적 상태
가루
색상
흰색에서 밝은 갈색까지
안정성
공급된 대로 1년 동안 안정적입니다. DMSO의 솔루션은 -20°에서 최대 3개월 동안 보관할 수 있습니다.

안전

WGK 독일 3

GSK 2334470 C화학적 특성, 용도, 생산

용도

GSK2334470 has been used as an inhibitor of 3-phosphoinositide dependent protein kinase-1 (PDK-1) in:
  • Treg cells, to identify regulators of interleukin 2 (IL-2)– signal transducer and activator of transcription 5 (STAT5) signaling
  • glycodelin-transfected HEC-1B human endometrial adenocarcinoma cells.
  • HeLa and Hs578T cells to test its effect on formylglycinamidine ribonucleotide synthase?(FGAMS) assembly

Biochem/physiol Actions

GSK2334470 (GSK-470) mediates cell cycle arrest. It also inhibits cellular proliferation and induces apoptosis in cancer cells.

GSK 2334470 준비 용품 및 원자재

원자재

준비 용품


GSK 2334470 공급 업체

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