NAMI-A

NAMI-A C화학적 특성, 용도, 생산

Pharmaceutical Applications

NAMI-A has shown activity in the treatment of metastatic cancer and has completed phase I clinical trials in the Netherlands. It has been shown that the complex is relatively nontoxic. Significantly higher doses than cisplatin (above 500 mg/m²/day) lead to side effects such as blisters on the extremities. Within the study, the ruthenium complex was administered intravenously over a period of 3 h in a 0.9% saline solution (pH～4) .
The NAMI-A is synthesised by reacting RuCl3?3H20 with HCl and DMSO (dimethylsulfoxide). This reaction results in the trans complex Imidazolium trans-imidazoledimethyl sulfoxide-tetrachlororuthenate(III) (NAMI-A) . It is interesting to note that Imidazolium trans-imidazoledimethyl sulfoxide-tetrachlororuthenate(III) is a paramagnetic compound and the complex is quickly hydrolysed in water. Initially, one chloride ligand is replaced by an aquo ligand, but the DMSO ligand is quickly replaced as well. As previously mentioned, it has been suggested that the complex is activated by bio-reduction of the Ru(III) centre to Ru(II) in the hypoxic environment of cancer cells. There is not much knowledge at present about the biological target for Imidazolium trans-imidazoledimethyl sulfoxide-tetrachlororuthenate(III). It is known that it interacts with the imidazoles of proteins and that the interaction with DNA is only weak, questioning DNA as a primary target for the ruthenium drug.

NAMI-A 준비 용품 및 원자재

원자재

준비 용품

NAMI-A 공급 업체

공급자	전화	이메일	국가	제품 수	이점
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
Musechem	+1-800-259-7612	info@musechem.com	United States	4662	60
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58
Absin Bioscience Inc.	021-38015121 15000105423	chenjw@absin.cn	China	24734	58
Shanghai hongqu biomedical technology co. LTD	88888888888	hongquchem@qq.com	China	5132	58
Energy Chemical	021-58432009 400-005-6266	marketing1@energy-chemical.com	China	44894	58
Beijing Jin Ming Biotechnology Co., Ltd.	010-60605840 15801484223	psaitong@jm-bio.com	China	29834	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24131	58
Suzhou Meishi Biotechnology Co., Ltd.	1173954148q	meishipharma@126.com	China	20035	58