FILGRASTIM

FILGRASTIM 구조식 이미지
카스 번호:
121181-53-1
상품명:
FILGRASTIM
동의어(영문):
Figrastim;FILGRASTIM;Filgrastim CRS;FILGRASTIM USP/EP/BP;Filgrastim DISCONTINUED;filgrastimconcentratedSolution;n-l-methionyl-colony-stimulatingfactor(humanclone1034;Filgrastim for Bioassay (96,815 IU) (COLD SHIPMENT REQUIRED);Filgrastim System Suitability (COLD SHIPMENT REQUIRED) (1 mg);Colony-stiMulating factor (huMan clone 1034), N-L-Methionyl- (9CI)
CBNumber:
CB6324250
분자식:
W99
포뮬러 무게:
0
MOL 파일:
Mol file

FILGRASTIM 속성

저장 조건
-70°C
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
HS 번호 3002905150
유해 물질 데이터 121181-53-1(Hazardous Substances Data)
독성 LD50 oral in rat: > 3mg/kg
그림문자(GHS): GHS hazard pictograms
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H361 태아 또는 생식능력에 손상을 일으킬 것으로 의심됨 생식독성 물질 구분 2 경고 P201, P202, P281, P308+P313, P405,P501
예방조치문구:
P201 사용 전 취급 설명서를 확보하시오.
P202 모든 안전 조치 문구를 읽고 이해하기 전에는 취급하지 마시오.
P281 요구되는 개인 보호구를 착용하시오
P308+P313 노출 또는 접촉이 우려되면 의학적인 조치· 조언를 구하시오.
P405 밀봉하여 저장하시오.
P501 ...에 내용물 / 용기를 폐기 하시오.

FILGRASTIM C화학적 특성, 용도, 생산

개요

Filgrastim is a recombinant human granulocyte colony stimulating factor (G-CSF) indicated as an adjunct to cancer chemotherapy for patients with non-myeloid malignancies. It reduces the duration of chemotherapy-induced neutropenia by forcing immature leucocytes to differentiate into neutrophils, thereby decreasing the incidence and length of infections.Bone pain is the most significant side effect.Chugai launched the second G-CSF, lenograstim, in December 1991. Other potential uses include bone marrow transplants, myelodysplastic syndromes and febrilelchronic neutropenia.

화학적 성질

Clear, colourless or slightly yellowish liquid

용도

Filgrastim is a human granulocyte colony stimulating factor (G-CSF) used to treat neutropenia.

Indications

Filgrastim (Neupogen) is a human recombinant granulocyte colony–stimulating factor (rG-CSF) produced using recombinant DNA technology. It acts on precursor hematopoietic cells in the bone marrow by binding to specific receptors that stimulate cellular proliferation and differentiation into neutrophils. It also enhances some neutrophil functions, including phagocytosis and antibody-dependent killing.

Clinical Use

Filgrastim, G-CSF, Neupogen, stimulates the proliferation ofgranulocytes (especially neutrophils) by mobilizinghematopoietic stem cells in the bone marrow. The native protein is glycosylated.Filgrastim selectively stimulates proliferation and differentiationof neutrophil precursors in the bone marrow. Thisleads to the release of mature neutrophils into the circulationfrom the bone marrow. Filgrastim also affects mature neutrophilsby enhancing phagocytic activity, priming the cellularmetabolic pathways associated with the respiratoryburst, enhancing antibody-dependent killing, and increasingthe expression of some functions associated with cell surfaceantigens.
In patients receiving chemotherapy with drugs such ascyclophosphamide, doxorubicin, and etoposide, the incidenceof neutropenia accompanied by fever is rather high.Administration of G-CSF reduces the time of neutrophilrecovery and duration of fever in adults with acute myelogenousleukemia. The number of infections, days thatantibiotics are required, and duration of hospitalization arealso reduced.

부작용

The drug is generally well tolerated, with the major adverse reaction being mild to moderate bone pain secondary to stimulation of bone marrow proliferation.

FILGRASTIM 준비 용품 및 원자재

원자재

준비 용품


FILGRASTIM 공급 업체

글로벌( 41)공급 업체
공급자 전화 이메일 국가 제품 수 이점
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21667 55
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250
1026@dideu.com China 24099 58
AFINE CHEMICALS LIMITED
+86-0571-85134551
info@afinechem.com China 15394 58
GIHI CHEMICALS CO.,LIMITED
+8618058761490
info@gihichemicals.com China 50003 58
Chemwill Asia Co.,Ltd. 86-21-51086038
chemwill_asia@126.com CHINA 23931 58
Hangzhou Sage Chemical Co., Ltd. +86057186818502 13588463833
info@sagechem.com China 10269 58
Beijing HuaMeiHuLiBiological Chemical 010-56205725
waley188@sohu.com China 12338 58
Chizhou Kailong Import and Export Trade Co., Ltd.
xg01_gj@163.com China 9503 50
Shanghai Synchem Pharma Co., ltd 21-619849051-1 18521059765
synchempharma@aliyun.com China 6463 55
Beijing Solarbio Science & Tecnology Co., Ltd. 010-50973186 4009686088
3193328036@qq.com China 18352 68

FILGRASTIM 관련 검색:

Copyright 2019 © ChemicalBook. All rights reserved