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FILGRASTIM

FILGRASTIM 구조식 이미지
카스 번호:
121181-53-1
상품명:
FILGRASTIM
동의어(영문):
FILGRASTIM;n-l-methionyl-colony-stimulatingfactor(humanclone1034;Colony-stiMulating factor (huMan clone 1034), N-L-Methionyl- (9CI)
CBNumber:
CB6324250
분자식:
W99
포뮬러 무게:
0
MOL 파일:
Mol file

FILGRASTIM 속성

저장 조건
-70°C
물리적 상태
neat

안전

HS 번호 3002905150

FILGRASTIM C화학적 특성, 용도, 생산

개요

Filgrastim is a recombinant human granulocyte colony stimulating factor (G-CSF) indicated as an adjunct to cancer chemotherapy for patients with non-myeloid malignancies. It reduces the duration of chemotherapy-induced neutropenia by forcing immature leucocytes to differentiate into neutrophils, thereby decreasing the incidence and length of infections.Bone pain is the most significant side effect.Chugai launched the second G-CSF, lenograstim, in December 1991. Other potential uses include bone marrow transplants, myelodysplastic syndromes and febrilelchronic neutropenia.

화학적 성질

Clear, colourless or slightly yellowish liquid

Originator

Amgen (U.S.A.)

용도

Antineutropenic; hematopoietic stimulant.

Indications

Filgrastim (Neupogen) is a human recombinant granulocyte colony–stimulating factor (rG-CSF) produced using recombinant DNA technology. It acts on precursor hematopoietic cells in the bone marrow by binding to specific receptors that stimulate cellular proliferation and differentiation into neutrophils. It also enhances some neutrophil functions, including phagocytosis and antibody-dependent killing.

상표명

Neupogen (Amgen).

Clinical Use

Filgrastim, G-CSF, Neupogen, stimulates the proliferation ofgranulocytes (especially neutrophils) by mobilizinghematopoietic stem cells in the bone marrow. The native protein is glycosylated.Filgrastim selectively stimulates proliferation and differentiationof neutrophil precursors in the bone marrow. Thisleads to the release of mature neutrophils into the circulationfrom the bone marrow. Filgrastim also affects mature neutrophilsby enhancing phagocytic activity, priming the cellularmetabolic pathways associated with the respiratoryburst, enhancing antibody-dependent killing, and increasingthe expression of some functions associated with cell surfaceantigens.
In patients receiving chemotherapy with drugs such ascyclophosphamide, doxorubicin, and etoposide, the incidenceof neutropenia accompanied by fever is rather high.Administration of G-CSF reduces the time of neutrophilrecovery and duration of fever in adults with acute myelogenousleukemia. The number of infections, days thatantibiotics are required, and duration of hospitalization arealso reduced.

Clinical Use

Filgrastim is used to accelerate recovery of neutrophils after chemotherapy, both to prevent infections and to shorten the duration of neutropenia in patients in whom infections have developed.

부작용

The drug is generally well tolerated, with the major adverse reaction being mild to moderate bone pain secondary to stimulation of bone marrow proliferation.

Veterinary Drugs and Treatments

Filgrastim may be of benefit in treating neutropenias in dogs or cats when the intrinsic response to endogenously produced cytokines is thought to be inadequate and there is evidence that there are precursors in the bone marrow available. Because of the drug’s cost and lack of good evidence for its efficacy in reducing mortality versus using antibiotic therapy alone, its use in small animal medicine is somewhat controversial.

FILGRASTIM 준비 용품 및 원자재

원자재

준비 용품


FILGRASTIM 공급 업체

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