LD50 (technical grade) orally in rats: >5000 mg/kg; dermally in rabbits: >4000 mg/kg; LC50 by inhalation in rats: >6.3 mg/l (Glover)
그림문자(GHS):
신호 어:
Warning
유해·위험 문구:
암호
유해·위험 문구
위험 등급
범주
신호 어
그림 문자
P- 코드
H319
눈에 심한 자극을 일으킴
심한 눈 손상 또는 자극성 물질
구분 2A
경고
P264, P280, P305+P351+P338,P337+P313P
예방조치문구:
P264
취급 후에는 손을 철저히 씻으시오.
P264
취급 후에는 손을 철저히 씻으시오.
P280
보호장갑/보호의/보안경/안면보호구를 착용하시오.
P305+P351+P338
눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P337+P313
눈에 대한 자극이 지속되면 의학적인 조치· 조언를 구하시오.
이마자목스 암모늄염 C화학적 특성, 용도, 생산
개요
Imazamox is registered throughout the world for use
in leguminous crops, including soybeans, alfalfa, and
edible beans, as well as in imidazolinone-resistant
crops (9). A nonionic surfactant or oil adjuvant is
required for maximum activity. Imazamox
is much more active when applied post-emergent to the
weeds compared with pre-emergence application (9). One
difference between imazamox and other imidazolinones is
the much shorter interval needed before sensitive follow
crops can be planted. This difference is due to the more
rapid degradation of imazamox in the soil compared with
other imidazolinones.
화학적 성질
Off-White Solid
용도
Imazamox is an imidazolinone based acetolactate synthase inhibitor that is utilized as a herbicide for weed control.
Pharmacology
Imazamox kills plants by inhibiting acetolactate synthase
(ALS) (I50 = 1 μM), which is the first common enzyme in
the biosynthesis of the branched chain amino acids, valine,
leucine, and isoleucine. Imazamox is rapidly absorbed
through the leaves of plants. Once it enters the plant,
imazamox rapidly translocates to the growing points and
growth ceases within 1 day after herbicide application,
followed by chlorosis and then by necrosis of the growing
points. Total plant death will occur within 2 to 3 weeks
after treatment.
신진 대사
Plant Metabolism. The selectivity of imazamox is due to
differential rates and routes of metabolism in tolerant
crops versus susceptible weeds (10). The primary
metabolic route is hydroxylation followed by conjugation
to glucose. In imidazolinone-resistant crops, the primary
mechanism of selectivity is due to an altered acetolactate
synthase that is not inhibited by imazamox (11).
Animal Metabolism. Metabolism studies in the rat
showed that imazamox is rapidly excreted in the urine.
There was no accumulation of imazamox or any of its
derivatives in the liver, kidney, muscle, fat, or blood (9).
