인간C5
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인간C5 속성
- 저장 조건
- -70°C
- 물리적 상태
- 액체
안전
위험품 표기 | B | ||
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WGK 독일 | 3 |
인간C5 C화학적 특성, 용도, 생산
용도
Complement C5 is part of the terminal sequence in the complement pathway. In particular, it is cleaved into C5a and C5b which are responsible for chemotaxis, inflammation, and initiating the formation of the membrane attack complex (MAC). Drugs that inhibit complement C5 have been used in Paroxysmal nocturnal hemoglobinuria (PNH) patients to lessen thrombotic complications by lessening intravascular hemolysis.일반 설명
Native, human C5 complement component. Glycoprotein composed of two non-identical subunits of M.W. 120 kDa (α) and 75 kDa (β) linked by disulfide bonds. Present in normal human serum at 70 μg/ml. Activation of complement via either the classical or alternative pathway can result in the assembly of C5-cleaving enzymes (C5 convertases) on target surfaces. Both C5 convertases cleave the C5 α-chain at peptide bond 74 resulting in production of C5a (M.W. 11,200) and C5b fragments (M.W. 185,000). Released C5a peptide is one of the three complement-derived anaphylatoxins. C5b fragment combines with C6, C7, C8, and C9 to form lytic C5b-9 complement membrane attack complex (MAC).Biochem/physiol Actions
Complement component C5 is processed by convertase enzymes in a cascade modulated in a unique way. The multi-subunit catalytic complex initially shows little activity against C5, but instead cleaves C3. A C3 cleavage product C3b covalently attaches to the complex and shifts its specificity to C5 by a factor of 1000.인간C5 준비 용품 및 원자재
원자재
준비 용품
인간C5 공급 업체
글로벌( 21)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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Aladdin Scientific | +1-+1(833)-552-7181 |
sales@aladdinsci.com | United States | 52927 | 58 |
Sigma-Aldrich | 021-61415566 800-8193336 |
orderCN@merckgroup.com | China | 51471 | 80 |
Biolab Reagents | 027-65279366 18162686757 |
products@biolabreagent.com | China | 9818 | 58 |
ACROBiosystems | 18514007688 |
jiaxin.zhao@acrobiosystems.com | China | 1011 | 58 |
인간C5 관련 검색:
실버 아세틸아세토네이트 디스프로슘 트리(2,2,6,6-테트라메틸-3,5-헵탄디오네이트) 아세틸아세토산 제2철 알루미늄 아세틸아세토네이트 코발트(II) 아세틸아세토네이트 하이드레이트 아세틸아세톤산 구리
Tris(2,4-pentanedionato)chroMiuM(III)
PHENYLSELENOL
Benzyl isocyanide
Ethyl isocyanoacetate
METHYL ISOCYANOACETATE
TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III)
1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE
Tosylmethyl isocyanide
SALCOMINE
N-BUTYLISOCYANIDE
DICHLORO(ETHYLENEDIAMINE)PLATINUM(II)
[18-PYROGLUTAMIC ACID]BIG GASTRIN I-(18-34)-PEPTIDE AMIDE, HUMAN