피모짓
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피모짓 속성
- 녹는점
- 214-218°
- 밀도
- 1.1763 (estimate)
- 저장 조건
- 2-8°C
- 용해도
- DMSO: 18mg/mL
- 산도 계수 (pKa)
- 7.32(at 25℃)
- 물리적 상태
- 흰색 고체
- 색상
- 미색에서 밝은 오렌지색까지
- 수용성
- 2.9mg/L(30℃)
- CAS 데이터베이스
- 2062-78-4(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
피모짓 C화학적 특성, 용도, 생산
개요
Pimozide is a dopamine receptor antagonist (Kis = 2.4, 0.3, and 1.8 nM for D2, D3, and D4 receptors, respectively). It also binds to eight additional receptors (Kds = 25-3,100 nM for the human receptors) and inhibits the voltage-gated sodium channel Nav1.2 and the voltage-gated potassium channel Kv11.1 (IC50s = 42 and 340 nM, respectively). Pimozide (0.5, 1, and 2 mg/kg) decreases the number of licks and reduces fluid intake of a sweetened solution in rats. It decreases the number of threats and attacks and increases immobility time in the neutral arena aggression test, indicating increased passiveness, in male mice when administered at a dose of 0.75 mg/kg for 10 days. Formulations containing pimozide have been used in the treatment of Tourette syndrome.화학적 성질
White or almost white powder.용도
Pimozide is a D2 dopamine receptor antagonist that binds to the cloned 5-HT7 receptor with high affinity (1,2,3,4). Pimozide is also a Ca2+ channel antagonist. Pimozide is used as an antipsychotic.정의
ChEBI: Pimozide is a member of the class of benzimidazoles that is 1,3-dihydro-2H-benzimidazol-2-one in which one of the nitrogens is substituted by a piperidin-4-yl group, which in turn is substituted on the nitrogen by a 4,4-bis(p-fluorophenyl)butyl group. It has a role as a H1-receptor antagonist, a serotonergic antagonist, a first generation antipsychotic, an antidyskinesia agent and a dopaminergic antagonist. It is a member of benzimidazoles, an organofluorine compound and a heteroarylpiperidine.일반 설명
Pimozide, 1-[1-[4,4-bis(p-fluorophenyl)butyl]-4-piperidyl]-2-benzimidazolinone (Orap), isa white to creamy white solid (pKa=9.42). Pimozide is 50%absorbed after oral administration. It is metabolized byCYP450 enzymes, in particular the CYP3A4 and CYP1A2isozymes, to inactive metabolites. Pimozide is excreted in theurine and to a lesser extent in the feces. Toxic effects may beproduced with pimozide in the presence of inducers or inhibitorsof CYP3A4 and CYP1A2. Pimozide is also a stronginhibitor of CYP2D6 without appearing to be an importantsubstrate of this isoform.99 The use of pimozide in the UnitedStates is small, but it is a critical drug for many patients withGilles de la Tourette disorder who cannot tolerate haloperidol.생물학적 활성
Dopamine D 2 -receptor antagonist and antipsychotic which binds with very high affinity to the cloned rat 5-HT 7 receptor (K i = 0.5 nM).피모짓 준비 용품 및 원자재
원자재
준비 용품
피모짓 공급 업체
글로벌( 128)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21667 | 55 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49392 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 |
sales@tnjchem.com | China | 34571 | 58 |
AFINE CHEMICALS LIMITED | +86-0571-85134551 |
info@afinechem.com | China | 15394 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 |
sales@sarms4muscle.com | China | 10522 | 58 |
CR Corporation Limited | +8613062833949 |
fred.wen@crcorporation.cn | China | 8647 | 58 |
Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 |
1026@dideu.com | China | 8672 | 58 |
Hebei Miaoyin Technology Co.,Ltd | +86-17367732028 +86-17367732028 |
kathy@hbyinsheng.com | China | 3581 | 58 |
Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 |
product@acmec-e.com | China | 33350 | 58 |
피모짓 관련 검색:
4-(2-케토-1-벤지미다졸린일)피페리딘 2-히드록시벤즈이미다졸
4,4'-Difluorodiphenylmethane
1-Methylpiperidin-4-amine
1,3-Propanediamine,N3,N3-dimethyl-1-phenyl-
N-(1-METHYLPIPERIDIN-4-YL)ANILINE
N,N,N',N'-TETRAMETHYL-1,3-BUTANEDIAMINE
1-METHYL-2-BENZIMIDAZOLINONE
1,3-Propanediamine,N3,N3-diethyl-1-phenyl-
1-Methyl-4-(methylamino)piperidine
N,N-Dimethylpiperidin-4-amine
Pimozide
4-AMINO-1-(1-PROPYL)-PIPERIDINE
N-(3-amino-1-methylpropyl)-N,N-dimethylamine
1-BUTYL-PIPERIDINE
1-ETHYL-PIPERIDIN-4-YLAMINE
N-phenylpiperidin-4-amine
1-(2-PROPYL)-2-BENZIMIDAZOLIDINONE