Cefditoren pivoxil
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Cefditoren pivoxil 속성
- 녹는점
- 207-209°C
- 알파
- D20 -48.5° (c = 0.5 in methanol)
- 밀도
- 1.55±0.1 g/cm3(Predicted)
- 저장 조건
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- 용해도
- DMSO(약간 용해됨), 에탄올(약간 용해됨), 메탄올(약간 용해됨, 가열)
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- 8.08±0.60(Predicted)
- 색상
- 황백색에서 연한 노란색
- Merck
- 14,1921
- CAS 데이터베이스
- 117467-28-4(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
RTECS 번호 | XI0367800 | ||
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HS 번호 | 2941.90.3000 |
그림문자(GHS): | |||||||||||||||||||||||
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신호 어: | Danger | ||||||||||||||||||||||
유해·위험 문구: |
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예방조치문구: |
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Cefditoren pivoxil C화학적 특성, 용도, 생산
개요
Cefditoren pivoxil is an orally active third generation cephalosporin introduced in Japan as a treatment for a broad range of bacterial infections including dermatological and other community acquired infections. Cefditoren pivoxil is reported to have a broad spectrum of activity against both Gram-positive and Gramnegative bacteria, more potent than many other existing agents of its class. In particular, it shows the highest therapeutic activity against S. pneumoniae and S. marcescens infections. It exhibits resistance to β-lactamase hydrolysis typical of third generation cephalosporins. As a prodrug of cefditoren, it is readily absorbed through GI tract and has low toxicity and side effects.화학적 성질
Off-White Powder용도
Cefditoren Pivoxil is an antibacterial and is a third generation cephalosporin.정의
ChEBI: The pivaloyloxymethyl ester prodrug of cefditoren.Antimicrobial activity
It exhibits good activity against staphylococci, streptococci (but not enterococci), H. influenzae and M. catarrhalis, including β-lactamase-producing strains. Isolates of Str. pneumoniae exhibiting reduced susceptibility to penicillin are less susceptible (MIC 0.125–2 mg/L). Most enterobacteria, including many Enterobacter, Citrobacter, Serratia and Proteus spp., are susceptible. It is not active against Ps. aeruginosa, Sten. maltophilia or atypical respiratory pathogens such as Chlamydophila pneumoniae and M. pneumoniae. It is stable to staphylococcal and common enterobacterial β-lactamases.Pharmacokinetics
Oral absorption: c. 70%Cmax 200 mg oral: c. 1.8 mg/L after 1.5–3 h
Plasma half-life: 0.8–1.3 h
Volume of distribution: 9.3 L
Plasma protein binding: 88%
After oral administration the pivaloyl ester is rapidly cleaved by esterases in the gut wall. Ingestion with food improves the bioavailability. Plasma concentrations are raised in elderly patients. There is no accumulation on repeated dosing.
It is excreted unchanged in the urine with a half-life of around 1.5 h, achieving a concentration of 150–200 mg/L within 4 h. Dosage adjustment is recommended in patients with deteriorating renal function.
Clinical Use
It has been advocated for community-acquired upper and lower respiratory tract infections and skin infections.부작용
In common with other pivoxil esters it may cause carnitine deficiency. Other side effects are those common to cephalosporins, mainly gastrointestinal disturbance.Cefditoren pivoxil 준비 용품 및 원자재
원자재
준비 용품
Cefditoren pivoxil 공급 업체
글로벌( 331)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29798 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 18629 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21667 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29888 | 58 |
Cangzhou Wanyou New Material Technology Co.,Ltd | 18631714998 |
sales@czwytech.com | CHINA | 906 | 58 |
Shanghai Longyu Biotechnology Co., Ltd. | +8619521488211 |
info@longyupharma.com | China | 2534 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39916 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49392 | 58 |
Hebei Runbin Biotechnology Co. LTD | 13180553332 |
2179877681@qq.com | CHINA | 996 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
Cefditoren pivoxil 관련 검색:
메틸(4-)-5-비닐티아졸
Cefditoren
Cefazedone
Ceftezole
(6R,7R)
Cefotetan disodium
Flomoxef
Sulbactam pivoxil
Cefoxitin
Ceftezole sodium
Cefoxitin sodium
Cefovecin Sodium
Cefetamet pivoxyl
Cefdinir
Methyl N,N-dimethylaminoacrylate
(6R,7R)-7-Amino-8-oxo-3-(1-propenyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
7-AVCA
Cefditoren pivoxil