RAC 8-HYDROXY EFAVIRENZ

RAC 8-HYDROXY EFAVIRENZ 구조식 이미지
카스 번호:
205754-33-2
상품명:
RAC 8-HYDROXY EFAVIRENZ
동의어(영문):
8-HydroxyEfavirenz;RAC 8-HYDROXY EFAVIRENZ;Efavirenz Impurity 11(8-Hydroxy Efavirenz);(4S)-6-chloro-4-(2-cyclopropylethynyl)-8-hydroxy-4-(trifluoromethyl)-1H-3,1-benzoxazin-2-one;6-Chloro-4-(cyclopropyl-d4-ethynyl)-1,4-dihydro-8-hydroxy-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one;2H-3,1-Benzoxazin-2-one,6-chloro-4-(cyclopropylethynyl)-1,4-dihydro-8-hydroxy-4-(trifluoromethyl)-, (4S)-;2H-3,1-Benzoxazin-2-one, 6-chloro-4-(2-cyclopropylethynyl)-1,4-dihydro-8-hydroxy-4-(trifluoromethyl)-, (4S)-;8-Hydroxy EfavirenzQ: What is 8-Hydroxy Efavirenz Q: What is the CAS Number of 8-Hydroxy Efavirenz Q: What is the storage condition of 8-Hydroxy Efavirenz Q: What are the applications of 8-Hydroxy Efavirenz
CBNumber:
CB7501021
분자식:
C14H9ClF3NO3
포뮬러 무게:
331.67
MOL 파일:
205754-33-2.mol

RAC 8-HYDROXY EFAVIRENZ 속성

녹는점
144-154°C
끓는 점
373.6±42.0 °C(Predicted)
밀도
1?+-.0.1 g/cm3(Predicted)
저장 조건
Store at -20°C
용해도
Acetonitrile: soluble; DMSO: soluble; Methanol: soluble
물리적 상태
고체
산도 계수 (pKa)
7.18±0.40(Predicted)

안전

RAC 8-HYDROXY EFAVIRENZ C화학적 특성, 용도, 생산

개요

8-hydroxy Efavirenz is a major oxidative metabolite of the non-nucleoside reverse transcriptase inhibitor efavirenz . 8-hydroxy Efavirenz is formed when efavirenz is metabolized by the cytochrome P450 (CYP) isoform CYP2B6. It induces apoptosis in rat primary hippocampal neurons and loss of dendritic spines in rat primary hippocampal neuronal cultures when used at a concentration of 0.01 μM.

화학적 성질

Off-White Solid

용도

A labellebed metabolite of Efavirenz, a nonnucleoside HIV-1 reverse transcriptase inhibitor

RAC 8-HYDROXY EFAVIRENZ 준비 용품 및 원자재

원자재

준비 용품


RAC 8-HYDROXY EFAVIRENZ 공급 업체

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