Docetaxel
|
|
Docetaxel 속성
- 녹는점
- 201-203 °C(Solv: methanol (67-56-1))
- 끓는 점
- 901.4±65.0 °C(Predicted)
- 밀도
- 1.36±0.1 g/cm3(Predicted)
- 저장 조건
- 2-8°C
- 용해도
- 클로로포름(약간 용해됨), 메탄올(약간 용해됨)
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- 11.20±0.46(Predicted)
- 색상
- 흰색에서 황백색까지
안전
Docetaxel C화학적 특성, 용도, 생산
용도
Docetaxal is an impurity of Docetaxel (D494420), a semisynthetic derivative of Paclitaxel (P132500). Docetaxel is an antimitotic agent that promotes the assembly of micro-tubules and inhibits their de -polymerization to free tubulin.일반 설명
Docetaxel is available in single-dose vials of 20 mg/0.5 mLand 80 mg/2 mL for IV administration in the treatment of breast, NSCLC, and prostate cancers. It has also been utilizedin non–FDA-approved treatment of head, neck, gastric,bladder, and refractory ovarian cancers.Docetaxel is highly plasma protein bound (80%) andwidely distributed with the highest concentration in the hepatobiliarysystem, but it does not appear to cross the bloodbrainbarrier. The metabolism of docetaxel has been lesswell studied than that of paclitaxel. The use of human livermicrosomes has indicated that metabolism involves oxidationof one of the tert-butyl methyl groups of the C-13 sidechain to initially give the alcohol. Further oxidation to thealdehyde and carboxylic acid both of which may cyclizewith the carbamate nitrogen to give stereoisomeric hydroxyoxazolidinonesand an oxazolidinedione, respectively. Noactive metabolites have been identified. The major enzymeinvolved is CYP3A4. The drug is primarily eliminated in thefeces with a terminal half-life of 11 hours.
The adverse effects profile for docetaxel is similar to thatof paclitaxel but also includes reversible fluid retention that isdose related. This has been associated with an initial increasein capillary permeability followed by a decrease in lymphaticdrainage later in the therapy. Restriction of sodium intake andpretreatment with corticosteroids is usually successful inminimizing this adverse effect. Peripheral neuropathy is seenwith docetaxel but occurs less often than with paclitaxel.Fatigue and muscle pain are commonly seen, and fever mayoccur in up to 30% of patients who are infection free.
Docetaxel 준비 용품 및 원자재
원자재
준비 용품
Docetaxel 공급 업체
글로벌( 203)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21666 | 55 |
Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 |
product@chemlin.com.cn | CHINA | 3012 | 60 |
Nanjing Finetech Chemical Co., Ltd. | 025-85710122 17714198479 |
sales@fine-chemtech.com | CHINA | 885 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29888 | 58 |
Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 |
admin@nexconn.com | China | 10311 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 |
linda@hubeijusheng.com | CHINA | 22968 | 58 |
Standardpharm Co. Ltd. | 86-714-3992388 |
overseasales1@yongstandards.com | United States | 14335 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39916 | 58 |
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD | +8615377521700 |
wangwendy93@gmail.com | China | 868 | 58 |
Docetaxel 관련 검색:
삼차부틸 아세트산 파클리탁셀 tert-부틸알코올 터트-부틸 퍼옥시아세테이트 클로로트리에틸실란
Docetaxel
DOCETAXEL HYDRATE,Docetaxel trihydrate
(2R,3S)-2-HYDROXY-3-(N-TERTBUTOXYCARBONYL) AMINO-3- PHENYL- METHYL PROPIONATE (INTERMEDIATE OF DOCETAXEL)
SIDE CHAINS OF DOCETAXEL--4
SIDE CHAINS OF DOCETAXEL--1
SIDE CHAINS OF DOCETAXEL--3
10-Oxo Docetaxel
13-O-(Triethylsilyl) Baccatin III
2-Debenzoyl-2-pentenoyl Docetaxel
Docetaxel Impurity 5
Docetaxel impurity 1/(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-acetoxy-6,9,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-4-(((2,2,2-trichloroethoxy)carbonyl)oxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl
Docetaxel Impurity 36
(2S,3S)-methyl 3-(tert-butoxycarbonylamino)-2-hydroxy-3-phenylpropanoate