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Anileridine

Anileridine 구조식 이미지
카스 번호:
144-14-9
상품명:
Anileridine
동의어(영문):
Adopol;Apidol;Alidine;Adopol-d4;Ethyl 1-(4;anileridine base;LKYQLAWMNBFNJT-UHFFFAOYSA-N;Anileridine (1.0 mg/mL in ethyl acetate);1-(p-AMinophenethyl)-4-phenylisonipecotic Acid Ethyl Ester;1-(p-AMinophenethyl)-4-phenylisonipecotic Acid-d4 Ethyl Ester
CBNumber:
CB81178032
분자식:
C22H28N2O2
포뮬러 무게:
352.47
MOL 파일:
144-14-9.mol

Anileridine 속성

녹는점
83°C
끓는 점
486.07°C (rough estimate)
밀도
1.1096 (rough estimate)
굴절률
1.6500 (estimate)
산도 계수 (pKa)
8.41±0.10(Predicted)
물리적 상태
Solid

안전

유엔번호(UN No.) 1544
위험 등급 6.1(b)
포장분류 III
유해 물질 데이터 144-14-9(Hazardous Substances Data)
독성 LD50 orl-rat: 175 mg/kg 27ZIAQ -,-,65

Anileridine C화학적 특성, 용도, 생산

Originator

Leritine HCl,Merck Sharp and Dohme,US,1958

용도

A synthetic analgesic drug. 4-phenylpiperidine derivative that is an analog of Meperidine (M223900) with increased analgesic activity.

정의

ChEBI: A piperidinecarboxylate ester that is the ethyl ester of isonipecotic acid in which the hydrogen alpha- to the carboxyl group is substituted by a phenyl group, and the hydrogen attached to the nitrogen is substituted by a 2-(4-aminophenyl) thyl group.

Manufacturing Process

A mixture of 7.8 grams (0.05 mol) of β-(p-aminophenyl)ethyl chloride hydrochloride, 12.5 grams (0.025 mol) of 4-phenyl-4-carboethoxypiperidine carbonate, 10.5 grams (0.125 mol) sodium bicarbonate, and 100 cc of anhydrous ethanol are mixed, stirred and heated under reflux for a period of approximately 40 hours and then concentrated in vacuum to dryness. The residual material is triturated with 50 cc of water, decanted, washed by decantation with an additional 50 cc of water, and then dried in vacuum to give N-[β-(p-aminophenyl)ethyl]-4-phenyl-4-carboethoxypiperidine.
The N-[β-(p-aminophenyl)ethyl]-4-phenyl-4-carboethoxypiperidine is dissolved in 50 cc of hot anhydrous ethanol, an excess (about 20 cc) of 20% alcoholic hydrochloric acid solution is added; upon scratching the side of the container crystals form. One hundred cubic centimeters of ether are then added to the mixture, the ethereal mixture is cooled, and the crystalline material which precipitates is recovered by filtration, washed with ether, and dried to give 12.7 grams of N-[β-(p-aminophenyl)ethyl]-4-phenyl-4-carboethoxypiperidine dihydrochloride which can be further purified by recrystallization from ethanol or methanal to give substantially pure material; MP 275-277°C.

상표명

Leritine (Merck).

Therapeutic Function

Narcotic analgesic

Safety Profile

Poison by ingestion,subcutaneous, intravenous, and intraperitoneal routes.When heated to decomposition it emits toxic fumes ofNOx.

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