antibacterial protein ll-37 amide (human)

antibacterial protein ll-37 amide (human) 구조식 이미지
카스 번호:
597562-32-8
상품명:
antibacterial protein ll-37 amide (human)
동의어(영문):
LL-37;LL-37 aMide;AntimicrobialPeptide,human;LL-37 amide (trifluoroacetate salt);Anti-LL37;Anti-CRAMP;Anti-HSD26;Anti-CAP18;Anti-FALL39;Anti-hCAP-18
CBNumber:
CB8217046
분자식:
C205H341N61O52
포뮬러 무게:
4492.27854
MOL 파일:
597562-32-8.mol

antibacterial protein ll-37 amide (human) 속성

저장 조건
-20°C
용해도
DMSO: Insoluble;Ethanol: 90 mg/mL (20.03 mM)
물리적 상태
완충 수용액
수용성
Water: 90 mg/mL (20.03 mM)
시퀀스
H-Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu -Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser-OH
InChIKey
JATXYCFPJFQHBQ-XAMSXPGMSA-N

안전

antibacterial protein ll-37 amide (human) C화학적 특성, 용도, 생산

개요

LL-37, also known as hCAP18, belongs to the cathelicidins family of antimicrobial peptides that possess strong antimicrobial activity across multiple species. In humans, this is the only cathelicidin present, and it is produced in epithelial cells through the proteolytic cleavage of the hCAP-18 protein. In addition to its antimicrobial properties, LL-37 also plays a crucial role in regulating the immune system. It can inhibit inflammatory responses by suppressing the activation of TLR2 and TLR4, which recognize different components of bacterial cell walls.

용도

LL-37 is a human antimicrobial peptide of the cathelicidin family and corresponds to the 134-170 segment of human cationic antimicrobial protein 18 (hCAP18). It plays an important role in the first line of defense against local infection and systemic invasion of pathogens at sites of inflammation and wounds. Cytotoxic to both bacterial and normal eukaryotic cells, LL-37 is significantly resistant to proteolytic degradation in solution.

Origin

LL-37 has been extensively studied since its discovery in 1995. This substance is a host defense peptide released by hCAP18 which is the only human cathelicidin.

antibacterial protein ll-37 amide (human) 준비 용품 및 원자재

원자재

준비 용품


antibacterial protein ll-37 amide (human) 공급 업체

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