PEPLOMYCIN SULFATE

PEPLOMYCIN SULFATE 구조식 이미지
카스 번호:
70384-29-1
상품명:
PEPLOMYCIN SULFATE
동의어(영문):
Pepleo;NK 631;Nsc276382;PEPLOMYCIN SULFATE;Pepleomycin Sulfate;N1-[3-[[(1S)-1-phenylethyl]aMino]propyl]bleoMycinaMide;N1-[3-[[(1S)-1-phenylethyl]amino]propyl]bleomycinamide Sulfate;Bleomycinamide, N1-[3-[(1-phenylethyl)amino]propyl]-, (S)-, sulfate (1:1) (salt)
CBNumber:
CB8413187
분자식:
C61H90N18O25S3
포뮬러 무게:
1571.67
MOL 파일:
70384-29-1.mol
MSDS 파일:
SDS

PEPLOMYCIN SULFATE 속성

녹는점
196-198°C
알파
25436 -2.0° (c = 1 in water)
용해도
DMSO, DMF, 메탄올, 물에 용해됨
물리적 상태
가루
산도 계수 (pKa)
2.9, 4.8, 7.4, 9.0(at 25℃)
색상
담황색 무정형

안전

독성 LD50 in male rats, mice (mg/kg): 234, 88 s.c.; 208, 85 i.p.; 245, 51 i.v. (Ito)
기존화학 물질 KE-28361

PEPLOMYCIN SULFATE C화학적 특성, 용도, 생산

개요

Peplomycin was derived biosynthetically from Streptomyces verticillus, the bleomycinproducing organism, in the course of efforts to obtain bleomycin derivatives with high activity and low toxicity. This antibiotic was found by Nippon Kayaku Co. and the Institute of Microbial Chemistry, Japan, in 1974. Its anticancer effects appear earlier than those of bleomycin; consequently, the period of therapy is shortened. Peplomycin is also active against metastatic cancer of the lymph nodes and shows less pneumotoxicity than bleomycin.

화학적 성질

Pale Yellow Amorphous Powder

Safety Profile

Poison by intraperitoneal, subcutaneous, and intravenous routes. Questionable carcinogen with experimental carcinogenic data. An eye irritant. When heated to decomposition it emits very toxic fumes of NOx and SOx.

PEPLOMYCIN SULFATE 준비 용품 및 원자재

원자재

준비 용품


PEPLOMYCIN SULFATE 공급 업체

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