L-시스테인 하이드로클로라이드
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L-시스테인 하이드로클로라이드 속성
- 녹는점
- ~215 °C (dec.)
- 용해도
- H2O: 0.5 M at 20 °C, 투명, 무색
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- CAS 데이터베이스
- 10039-26-6(CAS DataBase Reference)
안전
WGK 독일 | 3 | ||
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F 고인화성물질 | 3 |
L-시스테인 하이드로클로라이드 C화학적 특성, 용도, 생산
화학적 성질
White or almost white, crystalline powder.용도
Excipient.생산 방법
Lactose is a natural disaccharide consisting of galactose and glucose, and is present in the milk of most mammals. Commercially, lactose is produced from the whey of cows’ milk; whey being the residual liquid of the milk following cheese and casein production. Cows’ milk contains 4.4–5.2% lactose; lactose constitutes 38% of the total solid content of milk.a-Lactose monohydrate is prepared by crystallization from supersaturated solutions below 93.5°C. Various crystalline shapes are prism, pyramidal, and tomahawk; these are dependent on the method of precipitation and crystallization. Direct compression grades of a-lactose monohydrate are prepared by granulation/ agglomeration and spray-drying.
Pharmaceutical Applications
Lactose is widely used as a filler and diluent in tablets and capsules, and to a more limited extent in lyophilized products and infant formulas. Lactose is also used as a diluent in dry-powder inhalation; seeLactose, Inhalation. Various lactose grades are commercially available that have different physical properties such as particle size distribution and flow characteristics. This permits the selection of the most suitable material for a particular application; for example, the particle size range selected for capsules is often dependent on the type of encapsulating machine used. Usually, fine grades of lactose are used in the preparation of tablets by the wet-granulation method or when milling during processing is carried out, since the fine size allows better mixing with other formulation ingredients and utilizes the binder more efficiently.Other applications of lactose include use in lyophilized products, where lactose is added to freeze-dried solutions to increase plug size and aid cohesion. Lactose is also used in combination with sucrose (approximately 1 : 3) to prepare sugar-coating solutions. It may also be used in intravenous injections.
Lactose is also used in the manufacture of dry powder formulations for use as aqueous film-coating solutions or suspensions. Direct-compression grades of lactose monohydrate are available as granulated/agglomerated a-lactose monohydrate, containing small amounts of anhydrous lactose.
Direct-compression grades are often used to carry lower quantities of drug and this permits tablets to be made without granulation.
Other directly compressible lactoses are spray-dried lactose and anhydrous lactose; see Lactose, Spray-Dried and Lactose, Anhydrous.
저장
Mold growth may occur under humid conditions (80% relative humidity and above). Lactose may develop a brown coloration on storage, the reaction being accelerated by warm, damp conditions. The purities of different lactoses can vary and color evaluation may be important, particularly if white tablets are being formulated. The color stabilities of various lactoses also differ. Solutions show mutarotation.Lactose should be stored in a well-closed container in a cool, dry place.
비 호환성
A Maillard-type condensation reaction is likely to occur between lactose and compounds with a primary amine group to form brown, or yellow-brown-colored products. The Maillard interaction has also been shown to occur between lactose and secondary amine. However, the reaction sequence stops with the formation of the imine, and no yellow-brown coloration develops.Lactose is also incompatible with amino acids, amfetamines, and lisinopril.
Regulatory Status
GRAS listed. Included in the FDA Inactive Ingredients Database (IM, IV, and SC: powder for injections; oral: capsules and tablets; inhalation preparations; vaginal preparations). Included in nonparenteral and parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.L-시스테인 하이드로클로라이드 준비 용품 및 원자재
원자재
준비 용품
L-시스테인 하이드로클로라이드 공급 업체
글로벌( 150)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12456 | 58 |
Hebei Yanxi Chemical Co., Ltd. | +8617531190177 |
peter@yan-xi.com | China | 5993 | 58 |
Ouhuang Engineering Materials (Hubei) Co., Ltd | +8617702722807 |
admin@hbouhuang.com | China | 2991 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21691 | 55 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 |
alice@crovellbio.com | China | 8823 | 58 |
Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 |
sales@amoychem.com | China | 6387 | 58 |
BOC Sciences | +1-631-485-4226 |
inquiry@bocsci.com | United States | 19553 | 58 |
Antai Fine Chemical Technology Co.,Limited | 18503026267 |
info@antaichem.com | CHINA | 9641 | 58 |
Career Henan Chemica Co | +86-0371-86658258 15093356674; |
laboratory@coreychem.com | China | 30255 | 58 |
L-시스테인 하이드로클로라이드 관련 검색:
말토덱스트린 유당 알파-D-락토제 모노수화물 락토비온 산 알파-D-락토오스
3'-SIALYLLACTOSE
CDH
ALPHA-NEU5AC-[2->6]-BETA-GAL-[1->4]-BETA-GLCNAC-[1->3]-BETA-GAL-[1->4]-GLC SODIUM SALT
LACTOSE, MONOHYDRATE
CALCIUM LACTOBIONATE
D-Lactose monohydrate
D-Glucose monohydrate
LACTO-N-TETRAOSE
3'-N-ACETYLNEURAMIN-LACTOSE SODIUM SALT
LACTOSE OCTAACETATE
3-FUCOSYLLACTOSE
POTASSIUM LACTOBIONATE
BETA-GAL-[1->3]-BETA-GLCNAC-[1->3]-BETA-GAL-[1-4][ALPHA-FUC-(1->3)]-BETA-GLCNAC-[1->3]-BETA-GAL-[1->4]-GLC