Tranylcypromine
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Tranylcypromine 속성
- 녹는점
- 162-169 °C(lit.)
- 저장 조건
- 2-8°C
- 용해도
- 메탄올(약간 용해됨), 물(약간 용해됨)
- 물리적 상태
- 분말 또는 덩어리
- 색상
- 흰색~밝은 베이지
- optical activity
- [α]/D 1 to +1.0°, c = 1 in H2O
- 안정성
- 흡습성
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | T,Xn | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 36/37/38-25-20/21-52-22 | ||
| 안전지침서 | 45-36/37/39-26 | ||
| 유엔번호(UN No.) | 3249 | ||
| WGK 독일 | 3 | ||
| 위험 등급 | 6.1(b) | ||
| 포장분류 | III | ||
| HS 번호 | 29214990 |
Tranylcypromine C화학적 특성, 용도, 생산
화학적 성질
white to light beige powder or chunks용도
As with the MAO inhibitor drugs described above, tranylcypromine is also used for depressions that do not respond to other drugs.일반 설명
A cell-permeable phenylcyclopropylamine that inhibits the monoamine oxidase and histone demethylase activities, respectively, of MAO A/B (Ki = 101.9 and 16.0 M, respectively) and LSD1/2 (Ki = 242.7 and 180.0 M, respectively), four members of a flavin-dependent amine oxidase family enzymes, by a covalent adduct formation with the enzyme-bound FAD. In addition to preventing LSD1-CoREST (Corepressor of RE1-Silencing Transcription factor) complex-mediated H3K4 demethylation (IC50<2 M), TCP also inhibits LSD1-HCF-1 (Host Cell Factor-1) complex-mediated H3K9 demethylase activity, which is demonstrated to be an essential mechanism for the replication and latent infection of the α-herpesviruses HSV and VZV. The combined treatment of 2 M TCP and 10 M CHIR99061 is reported to enable the reprogramming of Oct4/Klf4-transduced primary HNEKs (Human Neonatal Epidermal Keratinocytes) into iPS (induced Pluripotent Stem) cells, albeit at a 100-time lower efficiency as seen in cultures transduced with 4-TFs (Oct44, Klf4, Sox2, and c-Myc).생물학적 활성
Irreversible inhibitor of lysine-specific demethylase 1 (LSD1/BHC110) and monoamine oxidase (MAO) (K i values are 242, 102 and 16 μ M for LSD1, MAO-A and MAO-B respectively). Inhibits histone demethylation.Tranylcypromine 준비 용품 및 원자재
원자재
준비 용품
Tranylcypromine 공급 업체
글로벌( 187)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21691 | 55 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 |
linda@hubeijusheng.com | CHINA | 22968 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 |
overseasales1@yongstandards.com | United States | 14336 | 58 |
| BOC Sciences | +1-631-485-4226 |
inquiry@bocsci.com | United States | 19553 | 58 |
| Chengdu Feibo Pharm Technology Co., Ltd | 15982321820 |
abby@arkpharm.com | CHINA | 3279 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49390 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; |
factory@coreychem.com | China | 29826 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | 18192627656 |
1012@dideu.com | China | 3422 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 |
info@antaichem.com | CHINA | 9641 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 |
joe@yuhengpharm.com | CHINA | 21149 | 58 |
Tranylcypromine 관련 검색:
시클로프로필아민
Yohimbine hydrochloride
TRANS-3-BENZYLOXYMETHYLCYCLOBUTANOL
TRANS-3-(TRIMETHYLSILYL)ALLYL ALCOHOL
TRANS-2-PHENYL-1-CYCLOPROPANECARBOXYLIC ACID
TRANS-2-PHENYLCYCLOPROPYLAMINE HYDROCHLO RIDE (TRANYLCYPROMINE HCL),TRANYLCYPROMINE
Tranylcypromine Hemisulfate
CYCLOPROPYLBENZENE
Tranylcypromine
dl-Tranylcypromine,Tranylcypromine (base and/or unspecified salts)
Dextroamphetamine hydrochloride
cis-Tranylcypromine hydrochloride
S-Tranylcypromine
Tranylcypromine-d5
TRANYLCYPROMINE-D5 HCL
R-Tranylcypromine
N-acetyl-tranylcypromine
dichlorobis(tranylcypromine)platinum(II)