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Brilacidin

Brilacidin 구조식 이미지

카스 번호:: 1224095-98-0

상품명:: Brilacidin

동의어(영문):: PMX 30063;Stroquinan;Brilacidin;4,6-Pyrimidinedicarboxamide, N4,N6-bis[3-[[5-[(aminoiminomethyl)amino]-1-oxopentyl]amino]-2-[(3R)-3-pyrrolidinyloxy]-5-(trifluoromethyl)phenyl]-

CBNumber:: CB92741737

분자식:: C40H50F6N14O6

포뮬러 무게:: 936.91

MOL 파일:: 1224095-98-0.mol

속성

안전

용도

공급 업체 19

Brilacidin 속성

밀도: 1.57±0.1 g/cm3(Predicted)

저장 조건: Store at -20°C

용해도: DMSO에 용해됨

산도 계수 (pKa): 9.47±0.70(Predicted)

안전

Brilacidin C화학적 특성, 용도, 생산

효소 저해제

This membrane-lyzing defensin mimetic (FW = 932.98 g/mol; CAS 1224095-98-0; IUPAC: N,N’-bis[3-{[5-(carbamimidoylamino)pentanoyl] amino}-2-[(3R)-pyrrolidin-3-yloxy]-5-(trifluoromethyl)phenyl]pyrimidine- 4,6-dicarboxamide)) is bactericidal (not simply bacteriostatic like most antibiotic) toward a broad spectrum of bacteria, but not mammalian cells. Brilacidin kills many Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA) and Enterococcus faecium as well as Gramnegative bacteria, including Eschericia coli and Klebsiella pneumonia (NDM). This action of this drug commend it for use in controlling Acute Bacterial Skin and Skin Structure Infections (ABSSSI). A five-day treatment course is usually effective in the treatment of many infections, and, given its direct membrane-disrupting action, bacteria are highly unlikely to acquire resistance to brilacidin.

Brilacidin 준비 용품 및 원자재

원자재

1-?Pyrrolidinecarboxyli?c acid, 3,?3'-?[4,?6-?pyrimidinediylbis[ca?rbonylimino[6-?[[5-?[[bis[[(1,?1-?dimethylethoxy)?carbonyl]?amino]?methylene]?amino]?-?1-?oxopentyl]?amino]?-?4-?(trifluoromethyl)?-?2,?1-?phenylene]?oxy]?]?bis-?, 1,?1'-?bis(1,?1-?dimethylethyl) ester, (3R,?3'R)?-

준비 용품

Brilacidin 공급 업체

글로벌( 19)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9348	55
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
BOC Sciences	+16314854226	inquiry@bocsci.com	United States	19743	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8617865335152	Mandy@hangyubiotech.com	China	11013	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131981	58
MedChemexpress LLC	021-58955995	sales@medchemexpress.cn	United States	4863	58
Shanghai Changyan Chem & Tech Co., Ltd.	021-021-20242659 18930833303	order@changyanchem.com	China	5008	55
Hangzhou Peptidego Biotech Co.,Ltd.	0571-87213919	eric@peptidego.com	China	6347	58
Fan De(Beijing) Biotechnology Co., Ltd.	15911056312	liming@bio-fount.com	China	9730	58
Zhejiang Huida Biotech Co., LTD	0571-89903882 13626641628	jiangnan@huidabiotech.com	China	3661	58