엔트렉티닙
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엔트렉티닙 속성
- 끓는 점
- 717.5±60.0 °C(Predicted)
- 밀도
- 1.340±0.06 g/cm3(Predicted)
- 저장 조건
- Store at -20°C
- 용해도
- ≥28.05 mg/mL in DMSO; insoluble in H2O; ≥9.82 mg/mL in EtOH with ultrasonic
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- 12.01±0.43(Predicted)
- 색상
- Off-white to light yellow
- InChIKey
- HAYYBYPASCDWEQ-UHFFFAOYSA-N
- SMILES
- C(NC1C2=C(NN=1)C=CC(CC1=CC(F)=CC(F)=C1)=C2)(=O)C1=CC=C(N2CCN(C)CC2)C=C1NC1CCOCC1
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
엔트렉티닙 C화학적 특성, 용도, 생산
개요
Entrectinib (RXDX-101, Ignyta Pharmaceuticals, San Diego, CA, USA) is a small molecule that inhibits the tyrosine kinases TRKA/B/C, ROS1, and ALK (Table?1). It has a preclinical median inhibitory concentration (IC50) of 7?nm against ROS1, higher than crizotinib [95, 96]. Entrectinib was specifically designed to cross the blood-brain barrier [95].용도
Entrectinib, also known as RXDX-101 and NMS-E628, is an oral small molecule inhibitor of TrkA, TrkB and TrkC, as well as ROS1 and ALK, with high potency and selectivity. RXDX-101 has demonstrated potent pharmacological activity in preclinical studies and has the potential to be first-in-class against the Trk family of kinases. PXDX-101 has been well tolerated in patients with advanced solid tumors. PXDX-101 is currently in clinical trials, and is being developed by Ignyta.상표명
RozlytrekClinical Use
Entrectinib demonstrated potent antitumor effects in tumor cell lines and patient-derived xenograft (PDX) tumor models in preclinical studies. Furthermore, entrectinib can cross the blood–brain barrier (BBB) to impact primary brain tumors and brain metastases in patients with NTRK1/ NTRK2/NTRK3, ROS1, and ALK fusion-driven cancers.엔트렉티닙 준비 용품 및 원자재
원자재
Benzamide, N-[5-[(3,5-difluorophenyl)methyl]-1H-indazol-3-yl]-4-(4-methyl-1-piperazinyl)-2-[(tetrahydro-2H-pyran-4-yl)(2,2,2-trifluoroacetyl)amino]-
Benzamide, 2-?amino-?N-?[5-?[(3,?5-?difluorophenyl)?methyl]?-?1H-?indazol-?3-?yl]?-?4-?(4-?methyl-?1-?piperazinyl)?-
3,5-Difluorobenzyl bromide
5-(3,5-difluorobenzyl)-2-fluorobenzonitrile
4-플루오로-2-니트로벤조산
tert-부틸4-(4-메틸피페라진-1-일)-2-니트로벤조에이트
4-Fluoro-2-Nitro-BenzoicAcidTert-부틸에스테르
tert-butyl 2-amino-4-(4-methylpiperazin-1-yl)benzoate
5-(3,5-difluorobenzyl)-1H-indazol-3-amine
4-(4-methylpiperazin-1-yl)-2-[(tetrahydropyran-4-yl)(2,2,2-trifluoroacetyl)amino]benzoic acid tert-butyl ester
4-(4-methylpiperazin-1-yl)-2-[(tetrahydropyran-4-yl)amino]benzoic acid tert-butyl ester
4-(4-methylpiperazin-1-yl)-2-[(tetrahydropyran-4-yl)(2,2,2-trifluoroacetyl)amino]benzoic acid trifluoroacetate
3-Cyano-4-fluorobenzeneboronic acid
Tetrahydro-4H-pyran-4-one
준비 용품
엔트렉티닙 공급 업체
글로벌( 193)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Zhengzhou Anhuida Chemical Co., Ltd | +8615903659408 |
admin@ahdchem.com | China | 297 | 58 |
Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 |
Mandy@hangyubiotech.com | China | 10991 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29798 | 60 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32836 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29888 | 58 |
TianYuan Pharmaceutical CO.,LTD | +86-755-23284190 13684996853 |
sales@tianpharm.com | CHINA | 304 | 58 |
Biochempartner | 0086-13720134139 |
candy@biochempartner.com | CHINA | 967 | 58 |
BOC Sciences | +1-631-485-4226 |
inquiry@bocsci.com | United States | 19553 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39916 | 58 |
Alchem Pharmtech,Inc. | 8485655694 |
sales@alchempharmtech.com | United States | 63711 | 58 |
엔트렉티닙 관련 검색:
Entospletinib (GS-9973)
4-[4-[[[[4-Chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-2-pyridinecarboxamide hydrate
Brigatinib
lenvatinib Mesylate
Dabrafenib
Trametinib
Regorafenib
Neratinib
Poziotinib (HM781-36B)
Dacomitinib (PF299804)
Cabozantinib Malate
Cediranib Maleate
Crizotinib
Afatinib (BIBW 2992)
Lorlatinib (PF-06463922)
AZD-9291
Nintedanib Ethanesulfonate Salt
Olaparib