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Entrectinib

Entrectinib 구조식 이미지
카스 번호:
1108743-60-7
상품명:
Entrectinib
동의어(영문):
CS-1589;NMS-E628;RXDX-101;Entrectinib;entrecitinib;Entrectinib(NMS-E628);Entrectinib(RXDX-101);Entrectinib,NMS-E628,RXDX-101;NMS E628; RXDX-101;NMSE628; RXDX 101;NMS-E628; RXDX101;RXDX101; RXDX 101; RXDX-101; NMS E628; NMSE628; NMS-E628; ENTRECTINIB
CBNumber:
CB93040787
분자식:
C31H34F2N6O2
포뮬러 무게:
560.64
MOL 파일:
1108743-60-7.mol

Entrectinib 속성

끓는 점
717.5±60.0 °C(Predicted)
밀도
1.340±0.06 g/cm3(Predicted)
산도 계수 (pKa)
12.01±0.43(Predicted)

안전

Entrectinib C화학적 특성, 용도, 생산

개요

Entrectinib (RXDX-101, Ignyta Pharmaceuticals, San Diego, CA, USA) is a small molecule that inhibits the tyrosine kinases TRKA/B/C, ROS1, and ALK (Table?1). It has a preclinical median inhibitory concentration (IC50) of 7?nm against ROS1, higher than crizotinib [95, 96]. Entrectinib was specifically designed to cross the blood-brain barrier [95].

Clinical Use

Entrectinib demonstrated potent antitumor effects in tumor cell lines and patient-derived xenograft (PDX) tumor models in preclinical studies. Furthermore, entrectinib can cross the blood–brain barrier (BBB) to impact primary brain tumors and brain metastases in patients with NTRK1/ NTRK2/NTRK3, ROS1, and ALK fusion-driven cancers.

Entrectinib 준비 용품 및 원자재

원자재

준비 용품


Entrectinib 공급 업체

글로벌( 133)공급 업체
공급자 전화 팩스 이메일 국가 제품 수 이점
Shanghai Payne Pharmaceutical Technology Co.Ltd
18678586262 021-58123769
info@paynepharm.com China 1355 58
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 26762 60
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29954 58
TianYuan Pharmaceutical CO.,LTD
+86-755-23284190 13684996853
+86-755-23284190 sales@tianpharm.com CHINA 305 58
Biochempartner
0086-13720134139
candy@biochempartner.com CHINA 968 58
BOC Sciences
1-631-485-4226
1-631-614-7828 inquiry@bocsci.com United States 19752 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 37282 58
Alchem Pharmtech,Inc.
8485655694
sales@alchempharmtech.com United States 63726 58
Zhuozhou Wenxi import and Export Co., Ltd
+8613111626072 (WhatsApp)
Wechat: +8613111626072 Wickr me: waynehu zzwenxi@126.com CHINA 13187 58
Zhengzhou Alfa Chemical Co.,Ltd
+8613343822234 +86-0371-55052911
sales5@alfachem.cn;sales9@alfachem.cn;sale1@alfachem.cn China 12031 58

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