Methyl (R)-(-)-3-hydroxybuty랫드 e
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Methyl (R)-(-)-3-hydroxybuty랫드 e 속성
- 알파
- -21.5 º (neat)
- 끓는 점
- 56-58 °C/11 mmHg (lit.)
- 밀도
- 1.055 g/mL at 20 °C (lit.)
- 굴절률
- n
20/D 1.421(lit.)
- 인화점
- 161 °F
- 저장 조건
- 2-8°C
- 용해도
- 클로로포름(약간 용해됨), 메탄올(약간 용해됨)
- 물리적 상태
- 기름
- 산도 계수 (pKa)
- 13.95±0.20(Predicted)
- 색상
- 무색
- optical activity
- [α]20/D 19.5°, neat
- 수용성
- 물에 약간 용해됩니다.
- BRN
- 3648161
- InChI
- InChI=1S/C5H10O3/c1-4(6)3-5(7)8-2/h4,6H,3H2,1-2H3/t4-/m1/s1
- InChIKey
- LDLDJEAVRNAEBW-SCSAIBSYSA-N
- SMILES
- C(OC)(=O)C[C@H](O)C
- LogP
- -0.412 (est)
- CAS 데이터베이스
- 3976-69-0(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xi | ||
---|---|---|---|
위험 카페고리 넘버 | 36/37/38 | ||
안전지침서 | 26-36/37-24/25-23 | ||
유엔번호(UN No.) | NA 1993 / PGIII | ||
WGK 독일 | 3 | ||
HS 번호 | 29181990 | ||
기존화학 물질 | KE-24283 |
Methyl (R)-(-)-3-hydroxybuty랫드 e C화학적 특성, 용도, 생산
화학적 성질
clear colorless liquid용도
Methyl (R)-3-hydroxybutyrate may be used in the preparation of (R)-(-)-3-hydroxybutanoic acid and poly-(R)-(-)-3-hydroxybutyrate.일반 설명
Methyl (R)-(-)-3-hydroxybutyrate is a monocarboxylic acid that is metabolized by phosphofructokinase and other enzymes to produce the corresponding 3-hydroxybutyrate. This compound is synthesized from tiglic acid, which can be obtained from corynebacterium. The production of it can be optimized by using a biotransformation process.Synthesis
In the glove box, put RuCl3 (0.69mg, 0.0033mmol), (R)-BINAP (2.3mg, 0.0036mmol), (1R,2R)-1,2-diphenyl-1,2-ethylenediamine (0.78 mg, 0.0036mmol) and isopropanol (150g) were added to a single-necked flask equipped with a magnetic stirrer, the stirring was turned on, the metal precursor and the ligand were dissolved and coordinated for 30 minutes,Obtain the catalyst solution, seal the single-neck bottle, take it out of the glove box, and pump it into a 0.5L reactor with a flat flow pump under the protection of nitrogen. The reactor has been replaced with nitrogen in advance, and the substrate methyl acetoacetate (116g, 1mol) and Potassium tert-butoxide (0.12g).After the catalyst solution was added, the reactor was replaced with hydrogen for three times, 8MPa hydrogen was charged, and the reactor was turned on for stirring and heating.When the internal temperature of the reactor reaches 100°C, open the hydrogen gas inlet valve, keep the internal pressure of the reactor at 10MPa, start timing, keep the reaction for 5 hours, the flowmeter shows that the hydrogen absorption rate is less than 0.1mL/min, terminate the reaction, and cool the reactor To room temperature, sampling and GC analysis showed that the conversion rate of raw material methyl acetoacetate was 99.9%, and the selectivity of (R)-1,3-butanediol was 8.8%.The ee value is 99.2%, and the selectivity of Methyl (R)-(-)-3-hydroxybutyrate is 90.9%.Methyl (R)-(-)-3-hydroxybuty랫드 e 준비 용품 및 원자재
원자재
TERT-BUTYL (R)-2-HYDROXYBUTYRATE
Ethyl (R)-3-hydroxybutyrate
(R)-3-Hydroxybutyric acid
(R)-(+)-Propylene oxide
아세토아세트산터셔리부틸에스테르
준비 용품
Methyl (R)-(-)-3-hydroxybuty랫드 e 공급 업체
글로벌( 347)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
ChiRial Biomaterial Co Ltd | +8619951673840 |
cero.xia@chirial.com | China | 156 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12456 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 15928 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21691 | 55 |
Chembon Pharmaceutical Co., Ltd. | +86-28-8425-2981 |
CHINA | 724 | 55 | |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9348 | 55 |
career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
Zhejiang ZETian Fine Chemicals Co. LTD | 18957127338 |
stella@zetchem.com | China | 2141 | 58 |
Accela ChemBio Inc. | (+1)-858-699-3322 |
info@accelachem.com | United States | 19965 | 58 |
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