1-[(AMMONIOOXY)METHYL]-4-CHLOROBENZENE CHLORIDE

1-[(AMMONIOOXY)METHYL]-4-CHLOROBENZENE CHLORIDE C화학적 특성, 용도, 생산

제조 방법

To a solution of 83.7 gm (1.5 moles) of potassium hydroxide in 560 ml of water is added in turn with stirring, 300 gm (0.985 mole) of dipotassium hydroxylaminedisulfonate and 161 gm (1.0 mole) of 4-chlorobenzyl chlo­ride. The stirred mixture is heated on a steam bath for 1.75 hr. After cool­ing, the precipitate is filtered off and refluxed for 3 hr in 1000 ml of 1.5 Ν sulfuric acid. The reaction mixture is then cooled and made strongly alkaline with a 15% aqueous sodium hydroxide solution. The mixture is then extracted with ether repeatedly. The ether extracts are combined and evaporated to dryness. The solid residue (crude free base, 80 gm, i.e., 51.5% of theory, m.p. 35-38°C) is taken up in 1 liter of ether. Anhydrous hydrogen chloride is bubbled through this solution to precipitate the hy­drochloride salt. The yield is 59 gm (31%, overall), m.p. 243-244°C (dec); the free base has b.p. 100°C/1 mm Hg. In this preparation, the hydrolysis of the alkylated dipotassium hydroxyl­aminedisulfonate with only 1 liter of 1.5 Ν sulfuric acid seems somewhat skimpy. We suggest that a higher level of sulfuric acid be considered at that stage of the reaction, if the alkylation has indeed gone to completion. Once the O-alkylhydroxylamine has been prepared by this reaction, it may be N-alkylated to produce an N,Ο-dialkylhydroxylamine.
The preparation of O-phenylhydroxylamine has been a synthetic chal­lenge for some time since it is quite unstable. Using hydroxylamine-O-sulfonic acid. A small quantity of this compound has been prepared [36]. Reaction conditions probably require further study to improve the yield. Extension of the reaction to the preparation of O-alkylhydroxylamines would be of interest.

1-[(AMMONIOOXY)METHYL]-4-CHLOROBENZENE CHLORIDE 준비 용품 및 원자재

원자재

준비 용품

1-[(AMMONIOOXY)METHYL]-4-CHLOROBENZENE CHLORIDE 공급 업체

공급자	전화	이메일	국가	제품 수	이점
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
SIMAGCHEM CORP	+86-13806087780	sale@simagchem.com	China	17367	58
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418671	sales@tnjchem.com	China	34572	58
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	info@dycnchem.com	CHINA	52867	58
PT CHEM GROUP LIMITED	+86-85511178 +86-85511178	peter68@ptchemgroup.com	China	35453	58
GIHI CHEMICALS CO.,LIMITED	+8618058761490	info@gihichemicals.com	China	49999	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131981	58
Mainchem Co., Ltd.	--	sarah@mainchem.com	China	6572	58

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