1-METHYL-D-TRYPTOPHAN manufacturers and suppliers

1-METHYL-D-TRYPTOPHAN suppliers

Properties

Melting point:: 242-245 °C(lit.)

alpha: 12.4o (C = 2 IN ACETIC ACID)

Boiling point:: 429.3±35.0 °C(Predicted)

Density: 1.28

storage temp.: Keep in dark place,Sealed in dry,Room Temperature

solubility: Soluble in DMSO (greater than 25 mg/ml).

pka: 2.26±0.10(Predicted)

form: White to light brown crystalline powder.

color: White

optical activity: [α]22/D +12.4°, c = 2 in acetic acid

Water Solubility: Soluble to 5 mM in water with gentle warming

Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.

InChIKey: ZADWXFSZEAPBJS-SNVBAGLBSA-N

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H315-H319-H335

Precautionary statements: P261-P305+P351+P338

WGK Germany: 3

Use

Indoleamine 2,3-dioxygenase (IDO) metabolizes tryptophan to kynurenine, leading to the production of NAD+ via the kynurenine pathway. The overexpression of IDO in tumors and tumor-draining lymph nodes induces immune tolerance and enhances tumor growth in vivo. 1-methyl-D-Tryptophan is an inhibitor of IDO (IC50 = 7 μM) that is effective in vivo. In mice, 1-methyl-D-tryptophan prevents T-cell anergy triggered by dendritic cells overexpressing IDO. It augments the antitumor and antiviral immunoresponse of CD8+ T-cells and reduces tumor volume in mice with xenografts overexpressing IDO. 1-methyl-D-Tryptophan, in combination with chemotherapy, causes regression of tumors and prolongs survival. Surprisingly, 1-methyl-D-tryptophan induces the expression of IDO in human ovarian carcinoma SKOV3 cells in culture.

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