Cephalexin manufacturers and suppliers

Cephalexin suppliers

Properties

Melting point:: 196-198°C

alpha: [α]D20 +144～+158° (c=0.5, H2O) (Calculated on dehydrous basis)

Boiling point:: 727.4±60.0 °C(Predicted)

Density: 1.3040 (rough estimate)

refractive index: 1.6320 (estimate)

storage temp.: Keep in dark place,Inert atmosphere,2-8°C

solubility: NH₄OH 1 M: 50 mg/mL, clear, yellow

form: Solid

pka: 5.2, 7.3(at 25℃)

color: White to light yellow

PH: pH (5g/l, 25℃) 3.5～5.5

Water Solubility: 12.5g/L(25 ºC)

Merck: 13,1986

BCS Class: 4

InChIKey: AVGYWQBCYZHHPN-CYJZLJNKSA-N

CAS DataBase Reference: 15686-71-2(CAS DataBase Reference)

EPA Substance Registry System: 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2R)-2-amino-2-phenylacetyl]amino]-3-methyl-8-oxo-, (6R,7R)- (15686-71-2)

Safety Information

Symbol(GHS): GHS08

Signal word: Danger

Hazard statements: H317-H334

Precautionary statements: P261-P272-P280-P284-P302+P352-P333+P313

Hazard Codes: Xn

Risk Statements: 42/43

Safety Statements: 22-36/37-45

WGK Germany: 3

RTECS: XI0350000

HS Code: 29419000

Hazardous Substances Data: 15686-71-2(Hazardous Substances Data)

Toxicity: TDLo orl-hmn: 14 mg/kg/D:GIT AACHAX -,361,68

Use

Cephalexin, 7α-(D-amino-α-phenylacetamido)-3-methylcephemcarboxylicacid (Keflex, Keforal), was designed purposelyas an orally active, semisynthetic cephalosporin. Theoral inactivation of cephalosporins has been attributed to twocauses: instability of the β-lactam ring to acid hydrolysis(cephalothin and cephaloridine) and solvolysis or microbialtransformation of the 3-methylacetoxy group (cephalothin,cephaloglycin). The α-amino group of cephalexin renders itacid stable, and reduction of the 3-acetoxymethyl to a methylgroup circumvents reaction at that site.Cephalexin occurs as a white crystalline monohydrate. Itis freely soluble in water, resistant to acid, and absorbed wellorally. Food does not interfere with its absorption. Becauseof minimal protein binding and nearly exclusive renal excretion,cephalexin is recommended particularly for the treatmentof urinary tract infections. It is also sometimes used forupper respiratory tract infections. Its spectrum of activity isvery similar to those of cephalothin and cephaloridine.Cephalexin is somewhat less potent than these two agentsafter parenteral administration and, therefore, is inferior tothem for the treatment of serious systemic infections.

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