Andrographolide manufacturers and suppliers

Andrographolide suppliers

Properties

Melting point:: 229-232 °C (lit.)

Boiling point:: 557.3±50.0 °C(Predicted)

alpha: -126 º (c=1.5,HAc)

Density: d421 1.2317

storage temp.: 2-8°C

solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 8 mg/ml).

pka: 12.36±0.20(Predicted)

form: Off-white solid

color: Off-white

optical activity: [α]20/D 126°, c = 1.5 in acetic acid

λmax: 223nm(MeOH)(lit.)

Merck: 14,633

BRN: 42762

Stability:: Stable for 2 years from date of purchsae as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

Cosmetics Ingredients Functions: SKIN CONDITIONING

InChI: 1S/C20H30O5/c1-12-4-7-16-19(2,9-8-17(23)20(16,3)11-21)14(12)6-5-13-15(22)10-25-18(13)24/h5,14-17,21-23H,1,4,6-11H2,2-3H3/b13-5+/t14-,15-,16+,17-,19+,20+/m1/s1

InChIKey: BOJKULTULYSRAS-QPSYGYIJSA-N

SMILES: C[C@@]1(CO)[C@H](O)CC[C@@]2(C)[C@H](C\C=C3/[C@H](O)COC3=O)C(=C)CC[C@H]12

LogP: 0.424 (est)

CAS DataBase Reference: 5508-58-7

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H302-H315-H319-H332-H335

Precautionary statements: P261-P280-P305+P351+P338

PPE: Eyeshields, Gloves, type N95 (US)

Hazard Codes: Xn

Risk Statements: 20/21/22-36/37/38

Safety Statements: 22-24/25-36-26

WGK Germany: 3

RTECS: LU3490750

HS Code: 29322980

Storage Class: 11 - Combustible Solids

Use

Andrographolide is a labdane diterpenoid. Andrographolide is the main bioactive component isolated from the medicinal plant Andrographis paniculata. It has a broad range of therapeutic applications including anti-inflammatory and anti-platelet aggregation activities and potential antineoplastic properties. Andrographolide showed significant antihepatotoxic action in P. berghei K173- induced hepatic damage in M. natalensis. Andrographolide inhibits tumor necrosis factor-α (TNF-α)-induced intercellular adhesion mol.-1 (ICAM-1) expression and adhesion of HL-60 cells onto human umbilical vein endothelial cells (HUVEC), which are associated with inflammatory diseases. These findings suggest that Andrographolide may have potential as a cardiovascular-protective agent.

You can find Andrographolide suppliers, manufacturers, and distributors from countries such as China, United States and the India here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.