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Andrographolide

Description References
Andrographolide
Andrographolide structure
CAS No.
5508-58-7
Chemical Name:
Andrographolide
Synonyms
ANDRO;ANDROGRAPHIS;Andrographolid;Andrographalide;ANDROGRAPHOLIDE;Rhizoma Sparganii;ANDROGRAPHOLIDE(P);Andrographolide (50 mg);5-alpha,6-alpha,8a-alpha))-t;Andrographis paniculata(Burm.f.)Nees
CBNumber:
CB1395576
Molecular Formula:
C20H30O5
Formula Weight:
350.45
MOL File:
5508-58-7.mol

Andrographolide Properties

Melting point:
229-232 °C(lit.)
alpha 
-126 º (c=1.5,HAc)
Density 
d421 1.2317
storage temp. 
+2C to +8C
form 
Off-white solid
optical activity
[α]20/D 126°, c = 1.5 in acetic acid
λmax
223nm(MeOH)(lit.)
Merck 
14,633
BRN 
42762
InChIKey
BOJKULTULYSRAS-QPSYGYIJSA-N
CAS DataBase Reference
5508-58-7

SAFETY

Hazard Codes  Xn
Risk Statements  20/21/22-36/37/38
Safety Statements  22-24/25-36-26
WGK Germany  3
RTECS  LU3490750
HS Code  29322980

Andrographolide price More Price(11)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 172060 Andrographolide 5508-58-7 50mg $64.4 2018-11-20 Buy
Sigma-Aldrich 1034862 Andrographolide United States Pharmacopeia (USP) Reference Standard 5508-58-7 50mg $469 2018-11-13 Buy
TCI Chemical A2459 Andrographolide >98.0%(HPLC) 5508-58-7 1g $18 2018-11-22 Buy
TCI Chemical A2459 Andrographolide >98.0%(HPLC) 5508-58-7 5g $55 2018-11-22 Buy
Cayman Chemical 11679 Andrographolide ≥98% 5508-58-7 50mg $15 2018-11-13 Buy

Andrographolide Chemical Properties,Uses,Production

Description

Andrographolide is the bitter principle, a colorless and neutral crystalline substance. It is the major labdane diterpenoid isolated from Andrographis paniculate. It exhibits antiviral, anti-inflammatory, and anticancer activities. The underlying mechanism is the inhibition of the mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) signaling (specifically p38 MAPK/ERK1/2) pathway and downstream transcription factors such as nuclear factor kappa B (NF-κB) and nuclear factor of activated T cells (NFAT). Andrographolide is also confirmed with chemopreventive effects against and the inhibitory effects on cancer cell growth in breast, colon, epidermoid, gastric, liver, leukemia, myeloma, peripheral blood lymphocytes, and prostate cancers.
Andrographolide has been used for liver complaints and fever, and as an anti-inflammatory and immunostimulant. Andrographolide exerts anti-growth and pro-apoptotic effects on human rheumatoid arthritis fibroblast- like synoviocytes, the main cellular constituent of pannus, that combined with a massive infiltration of lymphocytes and macrophages, invades and destroys the local articular structure. Thereby, andrographolide is proposed to be used in Rheumatoid Arthritis and other autoimmune diseases.

References

[1] Mari?a A. Hidalgo, Juan L. Hancke, Juan C. Bertoglio and Rafael A. Burgos (2013) Andrographolide a New Potential Drug for the Long Term Treatment of Rheumatoid Arthritis Disease in book “Innovative Rheumatology”
[2] https://www.drugs.com/npp/andrographis.html
[3] Mitchell Low, Cheang S Khoo, Gerald Münch, Suresh Govindaraghavan, Nikolaus J Sucher (2014) An in vitro study of anti-inflammatory activity of standardised Andrographis paniculata extracts and pure andrographolide, BMC Complementary and Alternative Medicine, 15:18

Chemical Properties

colorless Plates

Uses

Andrographolide is a labdane diterpenoid. Andrographolide is the main bioactive component isolated from the medicinal plant Andrographis paniculata. Andrographolide showed significant antihepatotoxic action in P. berghei K173- induced hepatic damage in M. natalensis. Andrographolide inhibits tumor necrosis factor-α (TNF-α)-induced intercellular adhesion mol.-1 (ICAM-1) expression and adhesion of HL-60 cells onto human umbilical vein endothelial cells (HUVEC), which are associated with inflammatory diseases. These findings suggest that Andrographolide may have potential as a cardiovascular-protective agent.

Uses

antineoplastic

Definition

ChEBI: A labdane diterpenoid isolated from the leaves and roots of Andrographis paniculata that exhibits anti-HIV, anti-inflammatory and antineoplastic properties.

Anticancer Research

It is a labdane diterpenoid, which shows cytotoxic effect against different cancercell lines like human epidermoid cancer cells (KB), lymphocytic leukemia cells(P388), breast cancer cells (MCF-7), and colon cancer cells (HCT-116). It inhibitsthe proliferation of colon cancer cells (HT-29) and exerts pro-differentiative effecton mouse myeloid leukemia M1 cell line (Desai et al. 2008).

Andrographolide Preparation Products And Raw materials

Raw materials

Preparation Products


Andrographolide Suppliers

Global( 328)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3203 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21968 58
Shanghai Bojing Chemical Co.,Ltd.
+86-21-37122233
+86-21-37127788 Candy@bj-chem.com CHINA 495 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20680 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682; +8618874586545
02783214688 bruce@xrdchem.cn CHINA 541 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24196 60
Xiamen AmoyChem Co., Ltd
+86 (0)592-605 1114
sales@amoychem.com CHINA 6374 58
Chengdu Biopurify Phytochemicals Ltd.
18080483897
maggie@biopurify.com CHINA 2236 58
Hubei Jusheng Technology Co.,Ltd.
86-188-71490254
peter@hubeijusheng.com CHINA 20095 58
Casorganics US Corp
+17326109938
sales@casorganics.com CHINA 141 58

View Lastest Price from Andrographolide manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-16 Andrographolide
5508-58-7
US $8.00 / kg 1kg 98% 10MT career henan chemical co
2018-04-11 2(3H)-Furanone
5508-58-7
US $10.00 / KG 10KG 99% 10MT Hubei XinRunde Chemical Co., Ltd.

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