ARANIDIPINE manufacturers and suppliers

ARANIDIPINE suppliers

ARANIDIPINE

CAS:: 86780-90-7

MF:: C19H20N2O7

MW:: 388.37

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Properties

Melting point:: 155°

Boiling point:: 530.0±50.0 °C(Predicted)

Density: 1.284±0.06 g/cm3(Predicted)

storage temp.: 2-8°C

solubility: DMSO : 125 mg/mL (321.86 mM)

pka: 2.56±0.70(Predicted)

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H302+H312+H332

Precautionary statements: P261-P264-P270-P271-P280-P301+P312+P330-P302+P352+P312+P362+P364-P304+P340+P312-P501

Toxicity: LD50 in male, female mice, rats (mg/kg): 143, 193, 1982, 1459 orally; LD50 in male, female mice (mg/kg): 7.3, 9.1 i.p. (Nakano)

Use

Aranidipine was launched in Japan as an antihypertensive agent. Its pharmacological effects are similar to other dihydropyridine derivatives, e.g., nefidipine, however, it is more potent and longer lasting. This is partially due to the fact that its initial metabolite (ketone reduction) is just as effective as the parent compound. Aranidipine exerts its activity by blocking Ca+2 entry during depolarization via L-type voltagegated Ca channels. This causes decreased levels of intracellular Ca which leads to enhanced relaxation of smooth and cardiac muscle. It is a selective α2-adrenoreceptor antagonist which inhibits vasoconstrictive responses. As a dihydropyridine derivative, it can be synthesized via a modified Hantsch synthesis. While sold as a racemate, the (S)-enantiomer is 150 times more active than the (R)- antipode.

You can find ARANIDIPINE suppliers, manufacturers, and distributors from countries such as CHINA, United States and the United Kingdom here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.