Bromoacetaldehyde dimethyl acetal manufacturers and suppliers

Bromoacetaldehyde dimethyl acetal suppliers

Properties

Boiling point:: 148-150 °C (lit.)

Density: 1.43 g/mL at 25 °C (lit.)

refractive index: n20/D 1.445(lit.)

Flash point:: 129 °F

storage temp.: 2-8°C

form: clear liquid

color: Colorless to Light orange to Yellow

Specific Gravity: 1.445

Water Solubility: insoluble

Sensitive: Moisture Sensitive

BRN: 1280132

Safety Information

Symbol(GHS): GHS02,GHS07

Signal word: Warning

Hazard statements: H226-H315-H319

Precautionary statements: P210-P302+P352-P305+P351+P338

Hazard Codes: Xi

Risk Statements: 10-36-36/37/38

Safety Statements: 26-36/39-28A-16

RIDADR: UN 1989 3/PG 3

WGK Germany: 3

F: 8-9-21

TSCA: Yes

HazardClass: 3

PackingGroup: III

HS Code: 29110000

Use

2-Bromo-1,1-dimethoxyethane (Bromoacetaldehyde dimethyl acetal) is used in the synthesis of 2,3-O-acetal via reaction with 2,3-diol in the presence of 10-camphorsulphonic acid (CSA). 2-bromo-1,1-dimethoxyethane was used to react with 4-hydroxylbenzaldehyde, and finally aldehyde substituted prodrug was generated by TFA-mediated deacetalization. It is widely used in chemistry for the synthesis of a variety of antibiotics (including erythromycin and cephalosporins) and other drugs. It is an important and highly reactive bifunctional compound with a good leaving group and a masked aldehyde function. It can be used as a starting material in a variety of reactions to provide N-alkylated compounds, lactams, aldehydes, oximes, azides, and acyclic di-/polyselenides.

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