Cemandil sodium salt manufacturers and suppliers

Cemandil sodium salt suppliers

Properties

Melting point:: 190-193°C

storage temp.: Inert atmosphere,Store in freezer, under -20°C

solubility: Freely soluble in water, sparingly soluble in methanol.

pka: 2.6-3.0(at 25℃)

color: White to Off-White

Water Solubility: Freely soluble in water. Sparingly soluble in methanol

Safety Information

Symbol(GHS): GHS07,GHS08

Signal word: Danger

Hazard statements: H315-H317-H319-H334-H335

Precautionary statements: P261-P280-P284-P304+P340-P305+P351+P338-P342+P311

Hazard Codes: Xn

Risk Statements: 36/37/38-42/43

Safety Statements: 26-36

WGK Germany: 3

RTECS: XI0380000

HS Code: 2941906000

Use

Cefamandole (Mandol) nafate is the formate ester ofcefamandole, a semisynthetic cephalosporin that incorporates D-mandelic acids as the acyl portion and a thiol-containingheterocycle (5-thio-1,2,3,4-tetrazole) in place of the acetoxylfunction on the C-3 methylene carbon atom. Esterification ofthe α-hydroxyl group of the D-mandeloyl function overcomesthe instability of cefamandole in solid-state dosage formsand provides satisfactory concentrations of the parent antibioticin vivo through spontaneous hydrolysis of the ester atneutral to alkaline pH. Cefamandole is the first second-generationcephalosporin to be marketed in the United States.The D-mandeloyl moiety of cefamandole appears toconfer resistance to a few β-lactamases, since some β-lactamase–producing, Gram-negative bacteria (particularlyEnterobacteriaceae) that show resistance to cefazolin andother first-generation cephalosporins are sensitive tocefamandole. Additionally, it is active against some ampicillin-resistant strains of Neisseria and Haemophilus spp.Although resistance to β-lactamases may be a factor in determiningthe sensitivity of individual bacterial strains tocefamandole, an early study indicated that other factors,such as permeability and intrinsic activity, are frequentlymore important. The L-mandeloyl isomer is significantlyless active than the D-isomer.Cefamandole nafate is very unstable in solution andhydrolyzes rapidly to release cefamandole and formate.There is no loss of potency, however, when such solutionsare stored for 24 hours at room temperature or up to 96hours when refrigerated. Air oxidation of the released formateto carbon dioxide can cause pressure to build up in theinjection vial.The D-mandeloyl moiety of Cemandil sodium salt appears toconfer resistance to a few β-lactamases, since some β-lactamase–producing, Gram-negative bacteria (particularlyEnterobacteriaceae) that show resistance to cefazolin andother first-generation cephalosporins are sensitive tocefamandole. Additionally, it is active against some ampicillin-resistant strains of Neisseria and Haemophilus spp.Although resistance to β-lactamases may be a factor in determiningthe sensitivity of individual bacterial strains tocefamandole, an early study indicated that other factors,such as permeability and intrinsic activity, are frequentlymore important. The L-mandeloyl isomer is significantlyless active than the D-isomer.

You can find Cemandil sodium salt suppliers, manufacturers, and distributors from countries such as China, United States and the United Kingdom here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.