Loteprednol etabonate manufacturers and suppliers

Loteprednol etabonate suppliers

Properties

Melting point:: 220.5-223.5

Boiling point:: 600.1±55.0 °C(Predicted)

Density: 1.31±0.1 g/cm3(Predicted)

storage temp.: -20°C

solubility: DMSO: soluble5mg/mL, clear (warmed)

form: powder

pka: 14.06±0.70(Predicted)

color: white to beige

Water Solubility: <1mg/L(23 ºC)

Stability:: Hygroscopic

InChIKey: DMKSVUSAATWOCU-ICASLIHPSA-N

Safety Information

Symbol(GHS): GHS08

Signal word: Warning

Hazard statements: H361-H413

Precautionary statements: P501-P273-P202-P201-P280-P308+P313-P405

WGK Germany: 3

HS Code: 2937.22.0000

Use

Loteprednol (as Loteprednol Etabonate) is a topical anti-inflammatory corticosteroid. Loteprednol etabonate (LE) has a 17-chloromethyl ester, in lieu of a ketone group, and a 17-etabonate group. LE is highly lipophilic and binds with high affinity to the glucocorticoid receptor. Any unbound LE is metabolized to inactive metabolites. Loteprednol etabonate is used in ophthalmic solution for the treatment of steroid responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea and anterior segment of the globe such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitis. It is used in ophthalmic ointment for the treatment of post-operative inflammation and pain following ocular surgery. As a nasal spray, it is used for the treatment and management of seasonal allergic rhinitis.

You can find Loteprednol etabonate suppliers, manufacturers, and distributors from countries such as China, India and the United States here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.