TALIPEXOLE manufacturers and suppliers

TALIPEXOLE suppliers

TALIPEXOLE

CAS:: 101626-70-4

MF:: C10H15N3S

MW:: 209.31

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Properties

Boiling point:: 364.6±37.0 °C(Predicted)

Density: 1.167±0.06 g/cm3(Predicted)

storage temp.: Store at -20°C

solubility: Soluble in DMSO

form: Powder

pka: 7.22±0.20(Predicted)

Safety Information

Use

Domin was launched in Japan for Parkinson's disease. The compound is readily accessible in two steps from I-allylhexahydro-4H-azepin4-one. Its antiparkinson activity resides in the fact that talipexole is a selective agonist for presynaptic dopamine D2 receptors with no D1 receptor activity. It is a clonidine-like α2-adrenoreptor agonist and has fewer GI side effects than bromocriptine the most widely used dopamine angonist. Also it is 70 times more potent than bromocriptine and has a more rapid onset of action. In addition to its anti-tremor activity there was a sedative effect but no emesis. The latter probably a result of talipexole's 5-HT3 receptor antagonistic activity. Its metabolites have no biological activity, there was no development of tolerence and its effect could be enhanced by L-dopa.

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