Welcome to chemicalbook!
400-158-6606
Inquriy
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook >> CAS DataBase List >> 1-METHYL-D-TRYPTOPHAN

1-METHYL-D-TRYPTOPHAN

1-METHYL-D-TRYPTOPHAN price.
  • $37 - $2320
  • Product name: 1-METHYL-D-TRYPTOPHAN
  • CAS: 110117-83-4
  • MF: C12H14N2O2
  • MW: 218.25
  • EINECS:
  • MDL Number:MFCD00274271
  • Synonyms:1-METHYL-D-TRYPTOPHAN;1-Methyl-D-tryptophane;1-METHYL-D-TRYPTOPHAN 95%;(R)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic acid;IndoxiMod;Indoximod (NLG-8189);NLG-8189;1-Me-D-Trp
19 prices
Selected condition:

Brand

  • Acrotein
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Cayman Chemical
  • ChemScene
  • DC Chemicals
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • Tocris
  • TRC

Package

  • 50mg
  • 200mg
  • 250mg
  • 500mg
  • 50
  • 1g
  • 5g
  • 10G
  • 25g
  • ManufacturerAcrotein
  • Product numberNA-2694
  • Product description1-Methyl-D-tryptophan 97%
  • Packaging1g
  • Price$165
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ52918
  • Product description1-Methyl-D-tryptophan
  • Packaging5g
  • Price$320
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberCHM0006850
  • Product description1-METHYL-D-TRYPTOPHAN 95.00%
  • Packaging1G
  • Price$679.28
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberCHM0006850
  • Product description1-METHYL-D-TRYPTOPHAN 95.00%
  • Packaging5G
  • Price$1085.24
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberCHM0006850
  • Product description1-METHYL-D-TRYPTOPHAN 95.00%
  • Packaging10G
  • Price$1622.89
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB4900
  • Product descriptionIndoximod(NLG-8189)
  • Packaging50mg
  • Price$38
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB4900
  • Product descriptionIndoximod(NLG-8189)
  • Packaging200mg
  • Price$63
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number16456
  • Product description1-methyl-D-Tryptophan ≥95%
  • Packaging250mg
  • Price$37
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16456
  • Product description1-methyl-D-Tryptophan ≥95%
  • Packaging500mg
  • Price$65
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16456
  • Product description1-methyl-D-Tryptophan ≥95%
  • Packaging1g
  • Price$115
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16456
  • Product description1-methyl-D-Tryptophan ≥95%
  • Packaging5g
  • Price$474
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-4941
  • Product descriptionIndoximod 99.39%
  • Packaging250mg
  • Price$60
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC8021
  • Product descriptionIndoximod(NLG-8189) >98%
  • Packaging1g
  • Price$450
  • Updated2021-12-16
  • Buy
  • ManufacturerMedical Isotopes, Inc.
  • Product number52384
  • Product description1-Methyl-D-tryptophan
  • Packaging25g
  • Price$2320
  • Updated2021-12-16
  • Buy
  • ManufacturerSigma-Aldrich
  • Product number452483
  • Product description1-Methyl-D-tryptophan 95%
  • Packaging250mg
  • Price$47
  • Updated2024-03-01
  • Buy
  • ManufacturerSigma-Aldrich
  • Product number452483
  • Product description1-Methyl-D-tryptophan 95%
  • Packaging1g
  • Price$146
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Acrotein NA-2694 1-Methyl-D-tryptophan 97% 1g $165 2021-12-16 Buy
AK Scientific J52918 1-Methyl-D-tryptophan 5g $320 2021-12-16 Buy
American Custom Chemicals Corporation CHM0006850 1-METHYL-D-TRYPTOPHAN 95.00% 1G $679.28 2021-12-16 Buy
American Custom Chemicals Corporation CHM0006850 1-METHYL-D-TRYPTOPHAN 95.00% 5G $1085.24 2021-12-16 Buy
American Custom Chemicals Corporation CHM0006850 1-METHYL-D-TRYPTOPHAN 95.00% 10G $1622.89 2021-12-16 Buy
ApexBio Technology B4900 Indoximod(NLG-8189) 50mg $38 2021-12-16 Buy
ApexBio Technology B4900 Indoximod(NLG-8189) 200mg $63 2021-12-16 Buy
Cayman Chemical 16456 1-methyl-D-Tryptophan ≥95% 250mg $37 2024-03-01 Buy
Cayman Chemical 16456 1-methyl-D-Tryptophan ≥95% 500mg $65 2024-03-01 Buy
Cayman Chemical 16456 1-methyl-D-Tryptophan ≥95% 1g $115 2024-03-01 Buy
Cayman Chemical 16456 1-methyl-D-Tryptophan ≥95% 5g $474 2024-03-01 Buy
ChemScene CS-4941 Indoximod 99.39% 250mg $60 2021-12-16 Buy
DC Chemicals DC8021 Indoximod(NLG-8189) >98% 1g $450 2021-12-16 Buy
Medical Isotopes, Inc. 52384 1-Methyl-D-tryptophan 25g $2320 2021-12-16 Buy
Sigma-Aldrich 452483 1-Methyl-D-tryptophan 95% 250mg $47 2024-03-01 Buy
Sigma-Aldrich 452483 1-Methyl-D-tryptophan 95% 1g $146 2024-03-01 Buy

Properties

Melting point :242-245 °C(lit.)
alpha :12.4o (C = 2 IN ACETIC ACID)
Boiling point :429.3±35.0 °C(Predicted)
Density :1.28
storage temp. :Keep in dark place,Sealed in dry,Room Temperature
solubility :Soluble in DMSO (greater than 25 mg/ml).
pka :2.26±0.10(Predicted)
form :White to light brown crystalline powder.
color :White
optical activity :[α]22/D +12.4°, c = 2 in acetic acid
Water Solubility :Soluble to 5 mM in water with gentle warming
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
InChIKey :ZADWXFSZEAPBJS-SNVBAGLBSA-N

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Indoleamine 2,3-dioxygenase (IDO) metabolizes tryptophan to kynurenine, leading to the production of NAD+ via the kynurenine pathway. The overexpression of IDO in tumors and tumor-draining lymph nodes induces immune tolerance and enhances tumor growth in vivo. 1-methyl-D-Tryptophan is an inhibitor of IDO (IC50 = 7 μM) that is effective in vivo. In mice, 1-methyl-D-tryptophan prevents T-cell anergy triggered by dendritic cells overexpressing IDO. It augments the antitumor and antiviral immunoresponse of CD8+ T-cells and reduces tumor volume in mice with xenografts overexpressing IDO. 1-methyl-D-Tryptophan, in combination with chemotherapy, causes regression of tumors and prolongs survival. Surprisingly, 1-methyl-D-tryptophan induces the expression of IDO in human ovarian carcinoma SKOV3 cells in culture.

Related product price